SUBSCRIBE

Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news

 

 

Chicken proteins may lower blood pressure: Study

By Stephen Daniells , 20-Oct-2008
Last updated on 20-Oct-2008 at 10:15 GMT2008-10-20T10:15:11Z

Collagen extracted from chicken legs may reduce blood pressure and potentially help against cardiovascular disease, according to a new study from Japan.

Hydrolysis of the chicken leg collagen led to angiotensin converting enzyme (ACE)-inhibitory activity, and feeding to hypertensive rats produced a 50 mmHg decrease in blood pressure, according to results published in the Journal of Agricultural and Food Chemistry.

ACE inhibitors work by inhibiting the conversion of angiotensin I to the potent vasoconstrictor, angiotensin II, thereby improving blood flow and blood pressure.

“Chicken collagen hydrolysate prepared in this study was composed of foods that can be easily incorporated into the daily diet,” wrote the authors from Nippon Meat Packers and Hiroshima University.

“It is important to prevent and improve hypertension, which is a lifestyle-related disease, in the course of daily life. By incorporating these foods into meals, normalization of blood pressure will be achieved without compromising the quality of life of those who need such foods.”

High blood pressure (hypertension),defined as having a systolic and diastolic blood pressure (BP) greater than 140 and 90 mmHg, is a major risk factor for cardiovascular disease (CVD) - a disease that causes almost 50 per cent of deaths in Europe, and reported to cost the EU economy an estimated €169bn ($202bn) per year.

Study details

The researchers, led by Ai Saiko, extracted collagen from chicken legs and hydrolysed them using the Aspergillus oryzae protease enzyme. The ACE-inhibitory activity was determined in vitro.

Different fractions exhibited different activities, with the hydrolysate with a molecular-weight of 3000 Da (low fraction) possessing the strongest ACE-inhibitory activity.

The researchers used various techniques to characterize and identify the active proteins and peptides, and the active sequence was identified as Gly-Ala-Hyp-Gly-Leu-Hyp-Gly-Pro.

An in vivo study with spontaneous hypertensive rats revealed that the low fraction led to a decrease in blood pressure two hours administration. A significant decrease of 50 mmHg was observed after six hours, said the researchers.

“Single oral administration of low molecular-weight chicken collagen hydrolysates significantly lowered the blood pressure in spontaneous hypertensive rats, and long-term oral administration even suppressed the hypertension in these animals,” wrote the researchers.

“It is thought that ACE-inhibitory peptides or potent inhibitory peptides in chicken collagen hydrolysate show hypotensive activity through gastrointestinal digestion and absorption,” they added.

Source: Journal of Agricultural and Food ChemistryVolume 56, Pages 9586-9591, doi: 10.1021/jf072669w“Angiotensin I-Converting Enzyme-Inhibitory Peptides Obtained from Chicken Collagen Hydrolysate”Authors: A. Saiga, K Iwai, T. Hayakawa, Y. Takahata, S Kitamura, T. Nishimura, F. Morimatsu

Related products

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Fytexia
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Indena
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Capsugel
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Ingredion
Balancing Innovation and Risk in Sports Nutrition Ingredients
NSF-International
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Roquette
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars

Promotional Features