Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news



CoQ10 and omega-3 show prostate benefits: RCT data

By Stephen DANIELLS , 12-Dec-2012
Last updated on 12-Dec-2012 at 16:22 GMT2012-12-12T16:22:51Z

CoQ10 and omega-3 show prostate benefits: RCT data

Daily supplements of coenzyme Q10 and omega-3 may offer potential prostate benefits by reducing levels of a PSA, linked to prostate cancer risk, says a new study.

Writing in the peer-reviews British Journal of Nutrition , Iranian scientists report that omega-3 and CoQ10 supplements independently reduced levels of prostate-specific antigen (PSA) levels in normal healthy men by 30 and 33%, respectively.

On the other hand, supplements containing the omega-6 fatty acid gamma-linolenic acid (GLA) were linked to increases in PSA levels. PSA is a marker commonly used to screen for prostate cancer and for tracking the disease after its diagnosis.

“These findings may have possible clinical implications,” wrote the researchers. “Dietary supplements containing n-3 PUFA or CoQ10 may have a protective effect against developing prostate cancer and/or a therapeutic effect in men with prostate cancer.”

Study details

Five hundred and four men were recruited to participate in the study, and were randomly assigned to receive CoQ10 (400 mg per day, Nutri Q10, Nutri Century), omega-3 (4.48 g of EPA and 2.88 g of DHA per day, EPAX 5500TG), GLA (2400mg, Vitex Pharmaceuticals Pty Ltd), or placebo for 12 weeks.

Results showed that the omega-3 and CoQ10 supplements were associated with 30% and 33% reductions in PSA levels, respectively, while GLA was associated with PSA increases of about 15%.

Commenting on the potential mechanisms of protection, the Tehran-based scientists note that omega-3 fatty acids may “exert their anti-tumor effect is by the anti-inflammatory effects of PUFA, through mediation of cyclo-oxygenase […] a key enzyme in fatty acid metabolism and inflammation”.

CoQ10, on the other hand, is an antioxidant, and may also function as a “non-specific stimulant for the immune system and a role in membrane stabilization, inhibition of intracellular phospholipases and stabilization of Ca-dependent slow channels”.

“The results from the present study suggest that men on EPA and CoQ10 supplementation may require a lower threshold (about 30 %) for PSA screening. However, these findings need to be interpreted with caution,” they said.

“Although statistically PSA was altered with the duration of treatment, longer studies are necessary to reach an appropriate conclusion. Also, studies need to be carried out to determine whether removal of the treatment allows the PSA values to return back to pre-treatment levels.”

Source: British Journal of Nutrition
November 2012, Volume 30, Pages 1-8, doi: 10.1017/S0007114512004783
“Effects of EPA, gamma-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial”
Authors: Safarinejad MR, Shafiei N, Safarinejad S.

Related products

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Balancing Innovation and Risk in Sports Nutrition Ingredients
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars