Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news



Industry dismisses recent calcium study as ‘flawed’

By Nathan Gray , 22-Apr-2011
Last updated on 22-Apr-2011 at 20:13 GMT2011-04-22T20:13:08Z

Following publication of a recent BMJ study slamming calcium supplements over their potential heart risks, industry has been keen to give its response to NutraIngredients.

The study, published in the British Medial Journal and reported by NutraIngredients here , warned that the risks of heart problems outweigh the potential benefits of calcium supplementation, with the lead researcher Professor Ian Reid saying that the results suggest that the indiscriminate use of calcium supplements ‘should be abandoned’.

However, leading industry figures have come out to counter-slam the results of the study, questioning the “flawed” methodology and statistical interpretation of the meta-analysis.

John Hathcock, senior vice president of scientific and international affairs at the Council for Responsible Nutrition (CRN) told NutraIngredients that he “wouldn’t put a lot of weight” on the conclusions, adding that he believed the methodology of the study “raises more questions than it provides answers.”

Rich history

Last year, Professor Reid and his research team published a study (reported here ) suggesting that regular calcium supplementation, taken to reduce the risk of osteoporosis may in-fact cause more heart attacks than the number of fractures they prevent.

The research team then re-analysed the data from this study, but this time included data of three new trials which looked at the effects of calcium plus vitamin D; something that the previous study received criticism for omitting last time around.

This new meta-analysis, with data from 29000 people, reported similar findings, suggesting that the risk of heart problems outweigh the potential benefits of calcium supplementation.

Flawed analysis?

“We saw this same flawed analysis last year with some slight changes, but we’re still looking at a meta-analysis of other studies […] This latest analysis does not present compelling evidence against calcium and vitamin D, and in fact, there are many more studies touting the beneficial effects for both,” said Dr. Cara Welch, vice president of scientific and regulatory affairs for the Natural Products Association (NPA).

Welch added that she hoped that individuals who use calcium supplements for bone health will continue supplementation “and not be swayed by this flawed analysis.

“We have seen over and over the argument that Americans can get all the nutrients they need from a balanced diet. But the fact is, most don’t,” she argued.

Hathcock of the CRN added to this sentiment by questioning the way the statictics have been interpreted in the new analysis:

“Instead of considering these findings a coincidence or a statistical abnormality as there are with many analyses of large pools of data with many variables, the authors instead suggest that the abrupt change in blood calcium levels after supplementation is what causes the effect … It seems more likely that findings are a procedural or statistical anomaly,” said Hathcock

However, Prof. Reid responded to the claims that the studies methods were flawed, telling NutraIngredients that the methodology and statistical rigour of the studies findings have been independently tested, and commended, on two occasions during the research’s review and publication process.

High stakes

Reid said that he knew the research findings would be “a high stake statement,” adding that the “net losers would of course be industry […] because it has substantial impact on all the people who take calcium and also on all the people who make it.”

“For that reason we have been expecting very close scrutiny and I think we have been particularly meticulous in the way we carried out this analysis so that any scrutiny doesn’t hold problems for us,” he said.

Further consideration

Harry Rice, V.P., Regulatory & Scientific Affairs for the United Natural Products Alliance (UNPA), told NutraIngredients that the he believes that the study provides “far too little evidence” to dictate public health policy.

“The reported results are interesting and there’s little doubt in my mind that the association between cardiovascular events and calcium supplementation with or without vitamin D warrants further consideration via future research,” said Rice.

Cathy Ross, senior cardiac nurse at the British Heart Foundation added to the calls for further investigation:

“The study showed there was a modest increase in heart attack or stroke risk but that’s not the same as saying calcium supplements with vitamin D cause heart attacks and strokes, only that there was an increased risk … It’s very important further studies are carried out to determine the effects of calcium supplements on heart health,” said Ross.

“There is still not enough evidence to confirm the association between calcium supplements and cardiovascular risk,” she added.

Related products

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Balancing Innovation and Risk in Sports Nutrition Ingredients
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars