SUBSCRIBE

Breaking News on Supplements, Health & Nutrition - EuropeUS edition

News > Research

Read more breaking news

 

 

‘Mini gut’ technology aims to make probiotic research more efficient and cheaper, says TNO

By Nathan Gray+

20-Feb-2013
Last updated on 20-Feb-2013 at 15:38 GMT2013-02-20T15:38:46Z

‘Mini gut’ technology to make probiotic research efficient and cheaper
‘Mini gut’ technology to make probiotic research efficient and cheaper
Loading the player...

A new technology that utilises intestinal stem cells to grown mini gut structures in the lab promises to help probiotic researchers achieve efficient and cost effective research, according to TNO.

The ‘mini guts’ – known as organoids – are fully functioning gut tissues that can be used by researchers to efficiently test the effect of dietary interventions on gut physiology and cellular signalling factors.

Speaking with NutraIngredients Sabina Lukovac of TNO Research in the Netherlands explained that the small gut structures can be grown in the lab from intestinal stem cells using specialised growth media and techniques.

“What we do is manipulate intestinal stem cells … in a way that we can make them self-renew, and grow into normal functional gut epithelial cells” said Lukovac.  “We can do this actually for different species.”

The researcher added that the original research was done on mouse gut cells, while TNO is now examining organoids different species – and is currently growing pig intestine organoids.

Screening platform

“The whole gut organoid system was set up to serve for regenerative medicine, so the innovative thing about TNO is that we want to use it for a totally different purpose,” said the innovation scientist.

“We want to use it as a screening platform,” she said, explaining that the system will be able to test food components such as probiotics, specific nutrients, and drugs. “There is a huge area of applications that you can think of, but right now we are focusing on probiotics.”

“It’s really physiologically relevant, so it doesn’t just represent one cell from the intestine, it represents the whole,” said Lukovac. “All the cells actually secrete hormones, they secrete antimicrobial peptides, so it’s really better than the existing in vitro system and it’s cheaper as well.” 

Overcoming the taboo of vaginal health – the next frontier of probiotics

Overcoming the taboo of vaginal health – the next frontier of probiotics

A paradigm shift is needed to force delicate women’s health issues like vaginal infections...

FiE 2015: Our best bits

FiE 2015: Our best bits

Our teams of journalists were out in force at Food Ingredients Europe (FiE) last...

New tech on EFSA’s horizon: Crowdsourcing and cyber assistants

New tech on EFSA’s horizon: Crowdsourcing and cyber assistants

New technology like crowdsourcing and artificial intelligence computers is the future of risk assessment,...

EFSA’s Bernhard Url: Science should reserve one private room for open debate

EFSA’s Bernhard Url: Science should reserve one private room for open debate

Since taking the European Food Safety Authority (EFSA) throne last summer, Dr Bernhard Url has become...

Seadragon sets out to breathe fire into Kiwi fish oil

Seadragon sets out to breathe fire into Kiwi fish oil

The town of Nelson will welcome New Zealand's first omega-3 fish oil processing plant...

The taste test: How do you make a probiotic drink taste good?

The taste test: How do you make a probiotic drink taste good?

Probiotic fruit drinks face different challenges to their dairy counterparts - but both face...

African probiotic project reaching 10,000 infants a day

African probiotic project reaching 10,000 infants a day

Professor Gregor Reid

Chair , University of Western Ontario & Human Microbiology and...

Germvangelist set to shake Probiota with holistic shout

Germvangelist set to shake Probiota with holistic shout

Jason Tetro

Researcher, author, The Germ Guy

Creepy proteins will be hot

New proteins are creeping on trend

Alternative proteins are a “hot area” of interest and products such as sandwich spreads...

Dairy ingredients giant on Indonesia: ‘A lot of opportunities here’

Dairy ingredients giant on Indonesia: ‘A lot of opportunities here’

Jake Riddle

General manager, Kerry Asia Pacific

The key to securing a sustainable omega-3 supply

Carrot vs. stick: What’s the key to securing a sustainable omega-3 supply?

With around 20-25% of global wild caught fish used for fish meal and fish...

GOED on doubling EFSA’s omega-3 recommendation

GOED on doubling EFSA’s omega-3 recommendation

Adam Ismail

Executive director , Global Organisation for EPA and DHA Omega-3s...

Protein chocolate set for mass-market after Mars & Snickers launches?

Mass-market future for protein chocolate after Mars and Snickers launches?

Protein experts at leading nutraceutical trade fair Vitafoods consider if protein chocolate has mainstream...

'It's still an attractive market': How are companies overcoming political instability in Turkey?

'It's still an attractive market': How are companies overcoming political instability in Turkey?

At the crossroads of east and west, Turkey offers huge promise but given the...

The ‘next generation’ of digestive health drinks? Rhythm tunes into consumer trends

The ‘next generation’ of digestive health drinks? Rhythm tunes into consumer trends

Rhythm Health believes its coconut-based kefir beverages and snacks can be the ‘natural successor’...

Video: Snacking can be a force for good, says nutrition specialist

Video: Snacking can be a force for good, says Campden BRI nutrition specialist

Food developers, manufacturers and ingredients suppliers gathered in Birmingham, UK, last month for a...

Consumers willing to pay more for bioavailability enhancements, consultant says

Consumers willing to pay more for bioavailability enhancements, consultant says

There is an opportunity for companies to use bioavailability enhancement to differentiate their products,...

What does it take to give a niche ingredient superfood staying power? A re-think of the supply chain

What does it take to give a niche ingredient superfood staying power? A re-think of the supply chain

What does it take to give a niche ingredient sustained consumer demand rather than...