SUBSCRIBE

Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news

 

 

Probiotics may ease eczema for children: RCT data

By Stephen Daniells , 08-Nov-2012
Last updated on 08-Nov-2012 at 16:24 GMT2012-11-08T16:24:50Z

Probiotics may ease eczema for children: RCT data

Daily supplements of the probiotic Lactobacillus plantarum CJLP133 may improve eczema in children, says a new study from South Korea.

The benefits were only observed during the supplementation period, and the probiotic did not persist in the gut after supplements were stopped, according to results published in Pediatric Allergy and Immunology .

Levels of white blood cells called eosinophils that control the mechanisms of allergy significantly decreased in children receiving the probiotic, compared with the placebo group, report researchers from Sungkyunkwan University School of Medicine, Samsung Medical Center, CJ Foods R & D Center, and Chung-Ang University College of Medicine.

Levels of the allergy marker interleukin-4 (IL-4) were also reduced in the probiotic group.

While the probiotic was associated with improvements in symptoms of eczema, the researchers caution that the long-term effects of the probiotic strain remain because it does not persist in the gut.

Probiotics for AD

Eczema, also known as atopic dermatitis, is one of the first signs of allergy during the early days of life and is said to be due to delayed development of the immune system. It is a common inflammatory skin disorder, which occurs in early childhood and may persists into adult life. According to the American Academy of Dermatologists it affects between 10 to 20% of all infants, but almost half of these kids will 'grow out' of eczema between the ages of five and 15.

Current treatments focus on alleviating symptoms, but probiotics have been studied for over 20 years for their therapeutic benefits for the condition, with numerous studies identifying significant strain-specific benefits.

Study details

The Korean researchers recruited 118 children with eczema aged between 1 and 13 to participate in their randomized, double-blind, placebo-controlled study. The children were randomly assigned to receive daily supplements of L. plantarum CJLP133 (CJ Cheiljedang Corp.) at a dosage of 5 billion colony-forming units. Eighty-three children completed the 12 week study.

Results showed that eczema scores, as measured by SCOring of Atopic Dermatitis (SCORAD) scores, changed by 9.1 points in the probiotic group, which was greater than 1.8 point change in the placebo group.

In addition, total eosinophil numbers were significantly lower at the end of the study, compared with numbers at the start.

“A reduction in eosinophil counts represents decreased disease activity, as there is a positive correlation between clinical severity and total eosinophil counts in acute exacerbation phase of atopic dermatitis,” they wrote.

The researchers note, however, that there were no statistical differences in the use of topical corticosteroids between the two groups.

The underlying mechanism of action is not known, they added, and this remains to be studied.

Source: Pediatric Allergy and Immunology
November 2012, Volume 23, Issue 7, pages 667–673, doi: 10.1111/pai.12010
“A randomized trial of Lactobacillus plantarum CJLP133 for the treatment of atopic dermatitis”
Authors: Han Y, Kim B, Ban J, Lee J, Kim BJ, Choi BS, Hwang S, Ahn K, Kim J.

Related products

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Fytexia
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Indena
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Capsugel
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Ingredion
Balancing Innovation and Risk in Sports Nutrition Ingredients
NSF-International
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Roquette
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars