SUBSCRIBE

Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news

 

 

Randomized trials show benefits of magnesium chelate ingredient

By Stephen Daniells , 06-Nov-2012
Last updated on 06-Nov-2012 at 14:55 GMT2012-11-06T14:55:04Z

The magnesium ingredient significant reduced pregnancy-related leg cramps
The magnesium ingredient significant reduced pregnancy-related leg cramps

Daily supplements of magnesium bisglycinate chelate may reduce the frequency and intensity of pregnancy-induced leg cramps, say results from a double-blinded, randomized, placebo-controlled trial.

Results published in the journal Maternal & Child Nutrition indicated that daily supplements of Albion’s magnesium bisglycinate chelate at a dose of 300 milligrams per day were associated with a reduction in both the frequency and intensity of leg cramps in healthy pregnant women.

“Magnesium bisglycinate chelate’s absorption rate is 2.2 times better than magnesium lactate or magnesium citrate; thus, it was chosen for this trial,” wrote researchers from Chulalongkorn University in Thailand.

“Therefore, we recommend this form of magnesium for […] pregnancy-induced leg cramps.”

Study details

The study involved 80 healthy pregnant women between 14 and 34 weeks of gestation who had leg cramps at least twice a week. The women were randomly assigned to receive placebo or magnesium bisglycinate chelate for four weeks.

Results indicated that a 50% reduction of leg cramp frequency was observed in 86% of the magnesium group, compared with 60% in the placebo group. In addition, a 50% reduction of leg cramp intensity was recorded in 69.8% of the women in the magnesium group, compared with 48.8% in the placebo group.

“There were no significant differences between the two groups in terms of side effects such as nausea and diarrhea,” added the researchers.

Cystic fibrosis benefits

In a separate trial with patients with cystic fibrosis, the same magnesium ingredient was found to improve the functional status of the respiratory musculature.

According to findings published in the American Journal of Clinical Nutrition indicated that magnesium bisglycinate chelate supplements at a daily dose of 300 milligrams were linked to a improvements in lung function of the patients, compared to placebo.

The researchers hypothesized that magnesium “may facilitate the removal of highly viscous mucus in chronic lung disease by activating endogenous DNase activity”.

 “Our double-blind, randomized, crossover study showed that children and adolescents with CF who receive conventional treatment in combination with oral magnesium bisglycinate chelate supplementation achieve significant improvement in functional status of the respiratory musculature and better clinical results,” concluded researchers from Federal University of Minas Gerais and the Federal University of Sao Joao del-Rei in Brazil.

Sources: Maternal & Child Nutrition
Published online ahead of print, doi: 10.1111/j.1740-8709.2012.00440.x
“Oral magnesium for relief in pregnancy-induced leg cramps: a randomised controlled trial”
Authors: C. Supakatisant, V. Phupong

American Journal of Clinical Nutrition
Published online ahead of print, doi: 10.3945/​ajcn.112.034207
“Oral magnesium supplementation in children with cystic fibrosis improves clinical and functional variables: a double-blind, randomized, placebo-controlled crossover trial”
Authors: C. Gontijo-Amaral, E.V. Guimaraes, P. Camargos

Related products

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Fytexia
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Indena
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Capsugel
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Ingredion
Balancing Innovation and Risk in Sports Nutrition Ingredients
NSF-International
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Roquette
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars