Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news



Resveratrol may improve mobility in older people: Animal data

1 commentBy Nathan Gray , 20-Aug-2012
Last updated on 20-Aug-2012 at 13:08 GMT2012-08-20T13:08:55Z

Resveratrol may improve mobility in older people

The red wine compound resveratrol could help older people to battle against motor deficiencies that lead to mobility problems and increased risks of falls, according to new research in mice.

The mouse data suggests that consumption of the red wine compound could help to improve mobility and prevent life-threatening falls among older people.

Speaking at the 244th National Meeting & Exposition of the American Chemical Society, Dr Jane Cavanaugh of Duquesne University, USA, revealed that the study findings – if found to be true in humans – could lead to the development of natural dietary products that boost the mobility and productivity of elderly people around the globe.

"Our study suggests that a natural compound like resveratrol, which can be obtained either through dietary supplementation or diet itself, could actually decrease some of the motor deficiencies that are seen in our aging population," said Cavanaugh. "And that would, therefore, increase an aging person's quality of life and decrease their risk of hospitalization due to slips and falls."

Study details

The new study, believed to be the first of its kind, fed young and old laboratory mice a diet containing resveratrol for eight weeks.

The team periodically tested the rodents' ability to navigate a steel mesh balance beam, counting the number of times that each mouse took a misstep.

Initially, the older mice had more difficulty manoeuvring on the obstacle, she revealed, but by the fourth week the older mice made far fewer missteps and were on par with the young mice.

In further work, Cavanagh's team found clues to how resveratrol might have such effects, she revealed.

Laboratory experiments, exposing neural cells to the dopamine, which in large amounts can induce cell death, she explained. However, neurons treated with resveratrol before being exposed to dopamine survive.

On closer examination, the researchers found that resveratrol lessened the damage done by oxygen free radicals generated by the breakdown of the dopamine, and activated protein signalling pathways that appeared to promote cell survival.

Although she is encouraged by the results, Cavanaugh noted that resveratrol does have some drawbacks in its natural form. For instance, it is poorly absorbed by the body. In fact, she calculates that a 150-pound person would have to drink almost 700 glasses of red wine a day to absorb enough resveratrol to get see beneficial effects. 

1 comment (Comments are now closed)

resveratrol dose

All those studies that apply resveratrol in very high dosage most likely observe polyphenol effect, but not a specific resveratrol effect, or the two together. Our studies and others' show that specific (and beneficial) resveratrol effects can be observed with 2 time 5-10 mg per day (for humans).

Report abuse

Posted by Laszlo G Meszaros
22 August 2012 | 08h562012-08-22T08:56:28Z

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Balancing Innovation and Risk in Sports Nutrition Ingredients
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars