SUBSCRIBE

Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news

 

 

Study suggests soy stops prostate cancer spread

By Jess Halliday , 17-Mar-2008

A new animal study has added to a body of research suggesting that soy could prove helpful in the fight against prostate cancer spreading to other parts of the body.

The same research team from Northwestern University previously established the mechanism by which genistein, an antioxidant from soy, inhibits detachment of cancer cells from a primary prostate tumour and represses cell invasion: by blocking activation of p38 MAP kinases molecules. The results of the new study, which appears in the March 15 issue of Cancer Research, give a new basis for hope that genistein could help prevent the spread of prostate cancer in patients, said senior investigator Raymond Bergan, MD. Bergan and his team fed genistein to several groups of mice, and then implanted them with an aggressive form of prostate cancer. The amount of genistein included in the creatures' chow was no higher than that which a human would consume as part of a diet that includes lots of soy. While the genistein did not seem to affect the size of prostate tumours in the mice, it did appear to completely stop lung metastasis (the spreading of cancer cells to other locations in the body). Metastases were seen to be decreased by 96 per cent. When Bergan examined the animals' tissue, measuring the size of the nuclei, he found that the cells had flattened out in order to spread. This, he said, demonstrates that the genistein has a primary effect on metastasis. In addition, the mice fed genistein were seen to express higher levels of genes involved in cancer cell migration. While this may seem to counter the study's overall conclusions, Bergan explained this as follows: "What we think is happening here is that the cells we put in the mice normally like to move. When genisten restricted their ability to do so, they tried to compensate by producing more protein involved in migration. But genistein prevented those proteins from being activated." There are limitations to the study, which Bergan noted. He said it may be that the effects of the compound in people who have eaten soy all their lives could be greater than in that seen in people who have only just started to eat genistein. The only real way to establish the potential of genistein, he said, is by conducting clinical trials. "Studies of antimetastatic efficacy in man are warranted and are under way," he wrote in his conclusion. Over half a million news cases of prostate cancer are diagnosed every year world wide, and the cancer is the direct cause of over 200,000 deaths. More worryingly, the incidence of the disease is increasing with a rise of 1.7 per cent over 15 years. Previous studies have indicated that men with a high risk of prostate cancer could benefit from a higher intake of soy isoflavones. For instance, a recent study published in the Journal of Nutrition (Vol 137, Pages 2258) investigated the potential of isoflavones to increase the excretion of two oestrogen metabolites suggested to initiate hormone-related cancers. Another study published in the same journal (Vol. 137, pp. 1974-1979) and in Cancer Epidemiol Biomarkers Prev (Vol. 16, pp. 538-545) claimed to be the first prospective study to report an inverse association between isoflavone and prostate cancer in Japanese men. Source Cancer Research 2008;68(6):2024-32 DOI: 10.1158/0008-5472.CAN-07-1246 "Dietary Genistein Inhibits Metastasis of Human Prostate Cancer in Mice" Authors: Minalini Lakshman, Li Xu, Vijayalakshmi Ananthanarayanan, Joshua Cooper, Chris H. Takimoto, Irene Helenowski, Jill Pelling and Raymond Bergan

Related products

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Fytexia
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Indena
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Capsugel
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Ingredion
Balancing Innovation and Risk in Sports Nutrition Ingredients
NSF-International
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Roquette
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars