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Vitamin B3 may benefit those with Parkinson's disease

1 commentBy Will Chu , 11-Jan-2017
Last updated on 11-Jan-2017 at 15:14 GMT2017-01-11T15:14:58Z

Worldwide 47.5m people have dementia and there are 7.7m new cases every year. ©iStock
Worldwide 47.5m people have dementia and there are 7.7m new cases every year. ©iStock

Individuals with a specific type of Parkinson's disease (PD) could gain from increasing vitamin B3 (niacin) content in their diet, say British investigators.

The findings point to niacin’s ability to increase levels of a compound responsible for energy generation and DNA repair.

These factors — if left unattended — result in faulty mitochondria function that contributes to the progression of the neuro-degenerative disorder.

"This study strengthens the therapeutic potential for Vitamin B3/niacin-based dietary interventions in the treatment of Parkinson's disease," said Dr Miguel Martins, lead study author and programme leader of the MRC Toxicology Unit at the University of Leicester.

Niacin or Vitamin B3 is found in a number of foods, including liver, chicken, beef, fish, cereal, peanuts, and legumes.

It can also be made from tryptophan, an essential amino acid found in most forms of protein.

Taking out the trash

The team began by looking at studying fruit flies, specifically bred with a mutation that mimics PD.

These flies specifically had a mutated form of the PINK1 gene that normally protects cells from stress-induced mitochondrial malfunction.  

Flies were then fed food supplemented with niacin, which is made into the compound NAD inside the body.

Niacin or Vitamin B3 is found in a number of foods, including liver, chicken, beef, fish and cereal. ©iStock

With this additional source of NAD, the researchers found flies had a lower number of faulty mitochondria than their mutant cohorts fed a regular diet.

In addition, niacin also prevented the flies from losing existing neurons.

“Mutations in PINK1 prevent cells from clearing out the defective powerhouses. When they accumulate, neurons can't get enough energy and die. The faulty mitochondria also release toxic molecules that damage their genes encoded by DNA,” said Dr Martins.

“With all the mitochondrial damage going on, we wondered if in cases of Parkinson's the NAD compound ends up in short supply."

The team also found that stopping DNA repair from depleting NAD kept mitochondria healthy and neurons alive, as well as enhance the flies' strength, mobility and lifespan.

"The results suggest that in familial Parkinson's, available NAD is critical for keeping mitochondria in shape and the disease at bay,” said Dr Martins.  

While drug treatments exist that block NAD-consumption during the DNA repair process, Dr Martins thought increasing dietary niacin could provide certain benefits.

"While neither of these would be cures, they would expand treatment options for Parkinson's patients with faulty mitochondria,” he added.

PINK1 profile

PINK1 activity causes the parkin protein to bind to faulty mitochondria inducing a self-destruct mechanism that disassembles unnecessary or dysfunctional components.

PINK1 is processed by healthy mitochondria and released to trigger neuron differentiation.

Parkinson's disease occurs when dopaminergic neurons in a specific part of the brain are lost.

EFSA guidance

The European Food Safety Authority (EFSA) currently recommends a population reference intake (PRI) of between 13.2 and 16.5 milligrams (mg) of niacin equivalent (NE) for Europeans.

These values take into account the production of niacin from the amino acid, tryptophan and consideration of calorie intake for adults, infants and children, pregnant and lactating women.

Previous studies have pointed towards the relationship between a high level of dietary niacin and a reduced risk of developing PD.

Altogether, these studies have demonstrated the therapeutic potential of a vitamin-enriched diet in an animal model of PD associated with mitochondrial dysfunction.

Based on this available evidence, the researchers thought that vitamin interventions might delay or prevent neurodegeneration in diseases associated with mitochondrial defects, such as PD.

However, they could not be considered potential ‘cures’ as they could not reverse the loss of specific populations of neurons that were absent at the time of diagnosis.

Source: Biology Open

Published online ahead of print: doi: 10.1242/bio.022186

“Enhancing NAD+ salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease.”

Authors: Susann Lehmann, Samantha Loh, L. Miguel Martins et al

1 comment (Comments are now closed)

how i get over my sickness

I was diagnosed of Parkinson's disease following a neurological examination and other series of tests, my symptoms first appeared in February 2014 tremor in both limbs, rigid muscle, impaired posture.. all medication prescribed were not working and i sadly took off from my job, being a single mother with two kids it was almost a hopeless situation. In September 2016, i read about Dr Abumere herbal center in a health forum, this herbal center have successful parkinson's disease herbal treatment and treatment for other list of terminal diseases, i contacted the herbal center via their email and purchased the parkinson's disease herbal remedy. I received the parkinson's disease herbal remedy via courier and immediately commenced usage. I used the remedy for 14 days, all my symptoms including tremor gradually disappeared till i almost forgot i had the disease, i have started working again, thanks to Dr Abumere herbal center. abumereherbalcentre@gmail.com Parkinson's disease is not a death sentence, don't die believing there is no cure, its a final breakthrough for all living with parkinson's disease.

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Posted by grannybee
03 March 2017 | 01h222017-03-03T01:22:27Z

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