Vitamin B3 may benefit those with Parkinson's disease
The findings point to niacin’s ability to increase levels of a compound responsible for energy generation and DNA repair.
These factors — if left unattended — result in faulty mitochondria function that contributes to the progression of the neuro-degenerative disorder.
"This study strengthens the therapeutic potential for Vitamin B3/niacin-based dietary interventions in the treatment of Parkinson's disease," said Dr Miguel Martins, lead study author and programme leader of the MRC Toxicology Unit at the University of Leicester.
Niacin or Vitamin B3 is found in a number of foods, including liver, chicken, beef, fish, cereal, peanuts, and legumes.
It can also be made from tryptophan, an essential amino acid found in most forms of protein.
Taking out the trash
The team began by looking at studying fruit flies, specifically bred with a mutation that mimics PD.
These flies specifically had a mutated form of the PINK1 gene that normally protects cells from stress-induced mitochondrial malfunction.
Flies were then fed food supplemented with niacin, which is made into the compound NAD inside the body.
With this additional source of NAD, the researchers found flies had a lower number of faulty mitochondria than their mutant cohorts fed a regular diet.
In addition, niacin also prevented the flies from losing existing neurons.
“Mutations in PINK1 prevent cells from clearing out the defective powerhouses. When they accumulate, neurons can't get enough energy and die. The faulty mitochondria also release toxic molecules that damage their genes encoded by DNA,” said Dr Martins.
“With all the mitochondrial damage going on, we wondered if in cases of Parkinson's the NAD compound ends up in short supply."
The team also found that stopping DNA repair from depleting NAD kept mitochondria healthy and neurons alive, as well as enhance the flies' strength, mobility and lifespan.
"The results suggest that in familial Parkinson's, available NAD is critical for keeping mitochondria in shape and the disease at bay,” said Dr Martins.
While drug treatments exist that block NAD-consumption during the DNA repair process, Dr Martins thought increasing dietary niacin could provide certain benefits.
"While neither of these would be cures, they would expand treatment options for Parkinson's patients with faulty mitochondria,” he added.
PINK1 profile
PINK1 activity causes the parkin protein to bind to faulty mitochondria inducing a self-destruct mechanism that disassembles unnecessary or dysfunctional components.
PINK1 is processed by healthy mitochondria and released to trigger neuron differentiation.
Parkinson's disease occurs when dopaminergic neurons in a specific part of the brain are lost.
EFSA guidance
The European Food Safety Authority (EFSA) currently recommends a population reference intake (PRI) of between 13.2 and 16.5 milligrams (mg) of niacin equivalent (NE) for Europeans.
These values take into account the production of niacin from the amino acid, tryptophan and consideration of calorie intake for adults, infants and children, pregnant and lactating women.
Previous studies have pointed towards the relationship between a high level of dietary niacin and a reduced risk of developing PD.
Altogether, these studies have demonstrated the therapeutic potential of a vitamin-enriched diet in an animal model of PD associated with mitochondrial dysfunction.
Based on this available evidence, the researchers thought that vitamin interventions might delay or prevent neurodegeneration in diseases associated with mitochondrial defects, such as PD.
However, they could not be considered potential ‘cures’ as they could not reverse the loss of specific populations of neurons that were absent at the time of diagnosis.
Source: Biology Open
Published online ahead of print: doi: 10.1242/bio.022186
“Enhancing NAD+ salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease.”
Authors: Susann Lehmann, Samantha Loh, L. Miguel Martins et al
