Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news



Vitamin D supplements may not offer osteoarthritis benefits: Study

1 comment

By Nathan Gray+


Vitamin D supplements may not offer osteoarthritis benefits: Study

Supplementation with vitamin D does not reduce key symptoms of osteoarthritis including cartilage loss and joint pain, according to the findings of a two year clinical trial.

The randomised clinical study – published in JAMA – investigated whether vitamin D supplementation was effective at reducing the symptoms and structural progression of knee osteoarthritis.

Led by Professor Timothy McAlindon from Tufts Medical Center, USA, the trial findings reveal that patients with symptomatic knee osteoarthritis who received vitamin D supplementation did not have a significant difference in primary outcome measures including knee pain and cartilage volume loss when compared to patients who received placebo.

“Vitamin D supplementation for 2 years at a dose sufficient to elevate 25-hydroxyvitamin D plasma levels to higher than 36 ng/mL, when compared with placebo, did not reduce knee pain or cartilage volume loss in patients with symptomatic knee OA,” wrote McAlindon and his colleageus.

“In summary, the results of this trial together with recent observational data indicate that vitamin D does not have a major effect on knee OA symptoms or progression among individuals who have a 25-hydroxyvitamin D level higher than 15 ng/mL,” they added.

Study details

The two-year randomised, placebo-controlled clinical trial included 146 participants with symptomatic knee OA. All participants were randomised to receive either placebo or oral cholecalciferol (2,000 IU/day) with dose escalation to increase serum levels to more than 36 ng/mL, the research team explained.

The primary measured outcomes for the study were knee pain severity (Western Ontario and McMaster Universities [WOMAC] pain scale), and cartilage volume loss measured by magnetic resonance imaging. Secondary outcomes included physical function, knee function (WOMAC function scale), cartilage thickness, bone marrow lesions, and radiographic joint space width.

“Knee pain fell by about 2 units in both groups,” said the team, who noted that the effect of treatment over time was not significant.

They added that cartilage volume decreased by around 4% in both the vitamin D and placebo groups.

Source: JAMA
Volume 309, Number 2, Pages 155-162, doi: 10.1001/jama.2012.164487  
"Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis. A Randomized Controlled Trial"
Authors: Timothy McAlindon, DMichael LaValley, Erica Schneider, Melynn Nuite, et al

1 comment (Comments are now closed)

knee ache

I am a big fan of your blog. i am so excited by read of your blog's content. really great post.Thanks for sharing superb informations. Your web-site is very cool. I am impressed by the details that you have on this blog.

Report abuse

Posted by arthritis
15 February 2013 | 06h502013-02-15T06:50:57Z

Related products

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Balancing Innovation and Risk in Sports Nutrition Ingredients
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars