Fat rats protected by plant sterols

- Last updated on GMT

Related tags: Plant sterols, Atherosclerosis

Obese rats with severe hypercholesterolemia - high blood
cholesterol - reacted positively to dietary supplementation with
plant sterols and minerals, according to research from Finland.

Obese rats with severe hypercholesterolemia - high blood cholesterol - reacted positively to dietary supplementation with plant sterols and minerals, according to research from Finland.

Researchers from the Institute of Biomedicine and Pharmacology at the University of Helsinki and the Department of Pathology, University of Helsinki Maria Hospital induced severe hypercholesterolemia in obese rats by feeding them with a diet high in fat, cholesterol and salt.

The diet was designed to induce atherosclerosis - the thickening and hardening of the arteries with deposits of fatty substances, cholesterol or other products. If left untreated, it can lead to heart attacks or strokes.

After their high fat diet, the rats showed a 10-fold increase in serum low-density lipoprotein (LDL or 'bad' cholesterol), as well as endothelial dysfunction, hypertension and vascular and renal damage.

However, after the diet was supplemented with plant sterols, and the salt partially replaced by calcium, magnesium and potassium, total and LDL cholesterol levels were lowered, as was the mean blood pressure. The supplementation also helped improve the function of the endothelium, the tissue located between the blood and the vessel wall which aids blood flow.

Plant sterols and the minerals also protected against vascular and renal damage and extended the lifespan of the rats, according to the research.

Related topics: Research, Suppliers, Healthy ageing

Related news

Related products

show more

Tipping the Scales for Healthy Weight

Tipping the Scales for Healthy Weight

Despite the current health and wellness craze, weight gain and obesity continue to rise. Whether a person gains or loses weight is a basic equation of...

Lutein. The Next New Vitamin?

Lutein. The Next New Vitamin?

Out of the 600 or more carotenoids found in nature, only three are found in the macula of the eye—lutein, RR-zeaxanthin and RS (meso)-zeaxanthin. These...

Outsmart brain-ageing in healthy older adults

Outsmart brain-ageing in healthy older adults

DIANA, FOOD DIVISION | 02-Apr-2019 | Technical / White Paper

What happens when you combine the brain health benefits of blueberries with those of grapes?
Both Canadian wild blueberries and French grapes are...

KERANAT™, the hair loss solution

KERANAT™, the hair loss solution

Robertet Health & Beauty | 25-Mar-2019 | Technical / White Paper

KERANAT's development is based on an innovative mechanism of action. KERANAT™ acts directly on the dermal papilla, the biological engine of hair,...

Related suppliers

Follow us

Featured Events

View more

Products

View more

Webinars