Anti-cancer support for omega-3

By Alex McNally

- Last updated on GMT

Omega-3 could help cut down colorectal cancer, if a new study in
mice can be translated to humans.

The study, by researchers from Harvard Medical School and Charité University Medicine, Germany, published in the journal Carcinogenesis​, says supplementation of omega-3 could be more useful at preventing colorectal cancer (CRC) than current drugs. Joint lead authors Johannes Nowak and Karsten Weylandt found that out of two sets of mice, the group with the highest amount of omega-3 in tissues showed some 15 per cent less inflammation in the colon. CRC is the second leading cause of cancer deaths in the United States and further work in this field could help find alternative to CRC drugs, which are reported to have side-effects over long-term use. Nowak and Weylandt said: "Dietary supplementation with​ omega-3 polyunsaturated fatty acids (n-3 PUFA) may be an effective and safe means of colorectal cancer prevention and it may be an alternative to the use of anti-inflammatory Cox-inhibitors, particularly Cox-2 inhibitors, which exhibit side effects when used for a long term. "Because n-3 PUFA have many other beneficial effects, such as cardioprotective effect, supplementation with n-3 PUFA to prevent colon cancer is a strategy worth pursuing now.​" The report adds more evidence to the anti-cancer effect of omega-3 and is the second study in the space of a week which adds support to the role of the oil as suppressing tissue inflammation. On Monday, reported on work by researchers in America, printed in the Journal of Biological Chemistry​, which found omega-3 was better at reducing prostanoids than omega-6. Prostanoids, when produced in excess, increase inflammation in various tissues and organs. In this mice study, Nowak and Weylandt found that an increased tissue content of omega-3 dampened colon inflammation. They said: "Our data provides new insight into the mechanism by which n-3 PUFA suppress tumorigenesis through dampening of inflammation and NF-?B activity. These results support a protective role of n-3 PUFA supplementation in the prevention of colorectal cancer."​ The results showed in the transgenic fat-1 mice overall tumor incidence was 87.5 per cent compared to 100 per cent in the wild-type animal. "The findings that increased tissue status of n-3 PUFA reduced colon inflammation and tumorigenesis in the fat-1 mice will lead to future studies to elucidate the molecular interactions and pathways underlying these effects​," the researchers concluded. Source: Carcinogenesis July 2007, doi:10.1093/carcin/bgm166 "Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids​." Authors:​ Johannes Nowak, Karsten Weylandt , Piet Habbel, Jingdong Wang, Axel Dignass, Jonathan Glickman, Jing Kang.

Related news

Show more

Related products

show more


The KGK Augmented RCT©

KGK Science, Inc. | 17-Jan-2018 | Technical / White Paper

The supplement industry currently finds itself in a similar state of affairs as the nascent pharmaceutical industry decades ago. Despite sophisticated...

Omegavie® DHA algae Qualitysilver®5

Omegavie® DHA algae Qualitysilver®5

POLARIS | 24-Nov-2017 | Data Sheet

Say  « Yes »   to Omegavie® DHA algae Qualitysilver®5 and enjoy the « green oil » of the future!Omegavie® DHA algae is a highly stable, non-GMO algal-based...

How Polyphenols enhance probiotic benefits

How Polyphenols enhance probiotic benefits

BerryPharma® - the Expert in Berry Extracts | 17-Oct-2017 | Research Study

Researchers have recently identified the positive interactions between polyphenols and intestinal bacteria, leading to classification as a prebiotic function....

Related suppliers

Follow us

Featured Events

View more


View more