Anti-cancer support for omega-3

By Alex McNally

- Last updated on GMT

Related tags: Essential fatty acid, Omega-3 fatty acid

Omega-3 could help cut down colorectal cancer, if a new study in
mice can be translated to humans.

The study, by researchers from Harvard Medical School and Charité University Medicine, Germany, published in the journal Carcinogenesis​, says supplementation of omega-3 could be more useful at preventing colorectal cancer (CRC) than current drugs. Joint lead authors Johannes Nowak and Karsten Weylandt found that out of two sets of mice, the group with the highest amount of omega-3 in tissues showed some 15 per cent less inflammation in the colon. CRC is the second leading cause of cancer deaths in the United States and further work in this field could help find alternative to CRC drugs, which are reported to have side-effects over long-term use. Nowak and Weylandt said: "Dietary supplementation with​ omega-3 polyunsaturated fatty acids (n-3 PUFA) may be an effective and safe means of colorectal cancer prevention and it may be an alternative to the use of anti-inflammatory Cox-inhibitors, particularly Cox-2 inhibitors, which exhibit side effects when used for a long term. "Because n-3 PUFA have many other beneficial effects, such as cardioprotective effect, supplementation with n-3 PUFA to prevent colon cancer is a strategy worth pursuing now.​" The report adds more evidence to the anti-cancer effect of omega-3 and is the second study in the space of a week which adds support to the role of the oil as suppressing tissue inflammation. On Monday, reported on work by researchers in America, printed in the Journal of Biological Chemistry​, which found omega-3 was better at reducing prostanoids than omega-6. Prostanoids, when produced in excess, increase inflammation in various tissues and organs. In this mice study, Nowak and Weylandt found that an increased tissue content of omega-3 dampened colon inflammation. They said: "Our data provides new insight into the mechanism by which n-3 PUFA suppress tumorigenesis through dampening of inflammation and NF-?B activity. These results support a protective role of n-3 PUFA supplementation in the prevention of colorectal cancer."​ The results showed in the transgenic fat-1 mice overall tumor incidence was 87.5 per cent compared to 100 per cent in the wild-type animal. "The findings that increased tissue status of n-3 PUFA reduced colon inflammation and tumorigenesis in the fat-1 mice will lead to future studies to elucidate the molecular interactions and pathways underlying these effects​," the researchers concluded. Source: Carcinogenesis July 2007, doi:10.1093/carcin/bgm166 "Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids​." Authors:​ Johannes Nowak, Karsten Weylandt , Piet Habbel, Jingdong Wang, Axel Dignass, Jonathan Glickman, Jing Kang.

Related news

Show more

Related products

show more

New frontiers in GUT HEALTH with Boswelllia serrata

New frontiers in GUT HEALTH with Boswelllia serrata

Indena: botanical ingredients for the Health Food industry | 18-Jun-2018 | Research Study

Bowellia serrata is renowned for its use in Ayurvedic medicine for various applications.
Its efficacy in GUT HEALTH is now validated with a more...

Making Health Claims on Infant Nutrition

Making Health Claims on Infant Nutrition

KGK Science, Inc. | 01-May-2018 | Technical / White Paper

The market for infant formula has expanded over the past decade and competition is high amongst leading manufacturers to make claims that differentiate...

Exploring Fibre Fermentation Profiles

Exploring Fibre Fermentation Profiles

Tate and Lyle | 27-Apr-2018 | Technical / White Paper

ProDigest developed the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®), which explores the fermentation profiles of fibres and evaluates...

Related suppliers

Follow us

Featured Events

View more


View more