Pomegranate juice may improve knee joint health: Study

By Stephen Daniells

- Last updated on GMT

Image: iStockPhoto / Ls9907
Image: iStockPhoto / Ls9907

Related tags: Pomegranate juice, Knee, Clinical trial, Knee osteoarthritis

Improvements in physical function and joint stiffness were recorded after six weeks of supplementation with pomegranate juice, report researchers.

The study is said to be the first clinical trial to investigate the potential benefits of pomegranate juice in people with osteoarthritis.

Writing in the peer-reviewed and PubMed listed Journal of the Science of Food and Agriculture​, ​Iranian scientists report that pomegranate juice consumption was associated with significant decreases in scores on the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) for physical function and stiffness.

The potential benefits were proposed to be linked to inhibition of matrix metalloproteinases (MMPs), which are known to play a role in the irreversible breakdown of cartilage. The researchers found that participants consuming the pomegranate juice had significantly lower levels of MMP-13, compared to the control group.

In addition, pomegranate juice was also found to increase glutathione peroxidase, an antioxidant enzyme.

The study adds to a long list of potential health benefits for the fruit. Pomegranate, a rich source of antioxidants, has been linked to improved heart health, prostate health, and joint health. It is these antioxidants, and particularly ellagitannin compounds like punicalagins and punicalins, which accounts for about half of the fruit's antioxidant ability, that are reportedly behind the proposed health benefits.

Study details

The researchers recruited 38 people with knee osteoarthritis and randomly divided them into two groups: One group received 200 mL per day of pomegranate juice; while the other group received no intervention.

pomegranate fruit seeds juice
Image © iStockPhoto

Results showed that, after six weeks of intervention, the WOMAC total score decreased in participants in the pomegranate juice from 39.6 to 32.4, while WOMAC scores in the control group increased slightly from 39.0 to 40.6.

In addition, scores of stiffness and physical function also improved significantly in the pomegranate juice group.

However, no effects for pain were observed, said the researchers.

“Further studies with longer intervention periods and a double-blind placebo controlled design are suggested to be done. Moreover, it is recommended to evaluate polyphenolic components in future surveys,” ​they concluded.

Source: Journal of the Science of Food and Agriculture
Published online ahead of print, doi: 10.1002/jsfa.7647
“The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis”
Authors: N. Ghoochani et al. 

Related news

Related products

show more

Adulteration: Don’t Be Fooled, Know the Facts

Adulteration: Don’t Be Fooled, Know the Facts

Sabinsa: our innovation is your answer® | 09-Jul-2018 | Technical / White Paper

Increased knowledge and awareness of natural products has in turn increased their global demand. This well documented paper highlights various examples,...

Optimise your training with OptiMSM®

Optimise your training with OptiMSM®

Gee Lawson Nutritional - LEHVOSS Group | 25-Jun-2018 | Technical / White Paper

For more than 25 years, OptiMSM® has set the quality standard for methylsulfonylmethane in dietary supplements, skin care, performance nutrition, and more.

New frontiers in GUT HEALTH with Boswellia serrata

New frontiers in GUT HEALTH with Boswellia serrata

Indena: botanical ingredients for the Health Food industry | 18-Jun-2018 | Research Study

Boswellia serrata is renowned for its use in Ayurvedic medicine for various applications.
Its efficacy in GUT HEALTH is now validated with a more...

Innovate in Joint Health with b-2Cool®

Innovate in Joint Health with b-2Cool®

BIOIBERICA, S.A. | 11-Jun-2018 | Data Sheet

b-2Cool® is a natural ingredient supplying native (undenatured) type II collagen.

b-2Cool® is manufactured through a strictly controlled...

Related suppliers

Follow us

Featured Events

View more

Products

View more

Webinars