Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news



Broccoli extract can ‘target’ cancer cells: Study

By Nathan Gray , 15-Jun-2011
Last updated on 17-Jun-2011 at 14:20 GMT2011-06-17T14:20:54Z

Broccoli extract can ‘target’ cancer cells: Study

The safety, and cancer-targeting ability of the broccoli extract sulforaphane, has been backed by a new study finding that it can selectively target cancer cells.

The research, published in Molecular Nutrition and Food Research, reports for the first time that sulforaphane – one of the primary phytochemicals in broccoli and other cruciferous vegetables – is able to selectively target and kill cancer cells, while leaving normal cells healthy and unaffected.

“It is well documented that sulforaphane can target cancer cells through multiple chemopreventive mechanisms," said the authors, led by Dr Emily Ho, associate professor at the Linus Pauling Institute at Oregon State University, USA.

“Here we show for the first time that sulforaphane selectively targets benign hyperplasia cells and cancerous prostate cells while leaving the normal prostate cells unaffected,” they added.

Broccoli benefit

The tissue of cruciferous vegetables, such as broccoli, cauliflower, and cabbage, contain high levels of the plant chemicals glucosinolates. These are metabolized by the body into isothiocyanates (such as sulforaphane), which have been suggested to be powerful anti-cancer agents.

As such, the potential health benefits of broccoli have led to a range of commercial supplements on the market. But Dr Ho said that it is important to demonstrate that sulforaphane is safe and effective for use in cancer prevention.

“Just because a phytochemical or nutrient is found in food doesn't always mean its safe, and a lot can also depend on the form or levels consumed,” she said.

“But [sulforaphane] does appear to be a phytochemical that can selectively kill cancer cells,” she affirmed.

Study details

The authors reported that SFN “selectively induced” cell death in cancer cell lines, but not in healthy cell tissue.

SFN exerts differential effects on cell proliferation, HDAC activity and downstream targets in normal and cancer cells.

The study also found that sulforaphane acts to inhibit histone deacetylase (HDAC) enzymes – a group of enzymes that play an important role in access to DNA and genes expression, including expression of tumor suppressor genes.

Due to its importance, HDAD inhibition is being targeted from both a pharmaceutical and dietary approach as important and promising field in cancer treatment, said the authors.

Ho and her colleagues said sulforaphane from dietary sources can help to turn on silenced genes and restore normal cellular function.

They added that their results “provide further support for the relevance of sulforaphane as a dietary HDAC inhibitor and chemopreventive [cancer preventing] agent” by showing that sulforaphane can selectively target cancer cells while leaving normal cells virtually unaffected.

Source: Molecular Nutrition & Food Research
Published online ahead of print, doi: 10.1002/mnfr.201000547
“Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells”
Authors: J.D. Clarke, A. Hsu, Z. Yu, R.H. Dashwood, E. Ho

Related products

Related suppliers

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Balancing Innovation and Risk in Sports Nutrition Ingredients
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars