SUBSCRIBE

Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news

 

 

Infant formula use linked to 'metabolic stress' and later disease risks: Study

By Nathan Gray+

13-Jun-2013
Last updated on 13-Jun-2013 at 12:40 GMT2013-06-13T12:40:38Z

Infant formula use linked to metabolic stress and later disease risks

Infants that are fed formula rather than breast milk may experience metabolic stress that plays a role in long suggested long-term risks for obesity, diabetes and other diseases, say researchers.

The new data, published in the Journal of Proteome Research, suggests that babied fed on formula, rather than breast milk, experience metabolic stress that play a role in long-recognised links between formula-feeding and an increased risk of obesity, type 2 diabetes and other conditions in adult life.

Led by Dr Carolyn Slupsky from the University of California, Davis, USA, the research team used an infant rhesus monkey model to comprehensively compare the metabolic implications of formula- and breast-feeding practices by measuring urinary and blood metabolites in addition to sampling cytokines and fecal microbial profiles.

"We show that formula-fed infants are larger than their breast-fed counterparts and have a different gut microbiome that includes higher levels of bacteria from the Ruminococcus genus and lower levels of bacteria from the Lactobacillus genus," explained Slupsky and her colleagues - adding that the formula-fed infants also had higher serum insulin coupled with higher amino acid levels, while amino acid degradation products were higher in breast-fed infants.

"Our findings support the contention that infant feeding practice profoundly influences metabolism in developing infants and may be the link between early feeding and the development of metabolic disease later in life," they suggested.

Study details

Slupsky and her colleagues used the rhesus monkey model to compare the comprehensive metabolic implications of formula- and breast-feeding practices using NMR spectroscopy to characterize metabolite fingerprints from urine and serum, in combination with anthropometric measurements, fecal microbial profiling, and cytokine measurements.

They found that the infant monkeys fed formula were larger, and had different microbiota make-up to their counterparts fed breast milk.

Indeed, they noted that the formula fed monkeys had higher levels of bacteria from the Ruminococcus genus and lower levels of bacteria from the Lactobacillus genus in their gut.

Additionally, the formula-fed infants were found to have higher serum insulin, coupled with higher amino acid levels - while amino acid degradation products were higher in breast-fed infants.

Slupsky and her team also observed increases in serum and urine galactose and urine galactitol in the second month of life in formula-fed infants - along with higher levels of immune factors including TNF-alpha, IFN-gamma, IL-1-beta, IL-4, and other cytokines and growth factors at week 4.

“These results demonstrate that metabolic and gut microbiome development of formula-fed infants is different from breast-fed infants and that the choice of infant feeding may hold future health consequences,” said Slumpsky and her colleageus.

Source: Journal of Proteome Research
Volume 12, Issue 6, Pages 2833–2845 doi: 10.1021/pr4001702
"Early Diet Impacts Infant Rhesus Gut Microbiome, Immunity, and Metabolism"
Authors: Aifric O’Sullivan, Xuan He, Elizabeth M. S. McNiven, et al

Related products

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Fytexia
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Indena
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Capsugel
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Ingredion
Balancing Innovation and Risk in Sports Nutrition Ingredients
NSF-International
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Roquette
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars