SUBSCRIBE

Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news

 

 

Lutein and zeaxanthin can benefit colon cancer, say researchers

By Shane Starling , 24-Oct-2008
Last updated on 24-Oct-2008 at 17:46 GMT2008-10-24T17:46:49Z

Korean researchers have found alga-extracted carotenoids such as lutein and zeaxanthin can reduce colon cancer growths.

The carotenoids extracted from two popular Asian algae forms – Chlorella ellipsoidea (CEE) and Chlorella vulgaris (CVE) – blocked growth of human colon cancer cells, the scientists found.

Lutein and zeaxanthin, more commonly known for eye health benefits, were not the only xanthophylls present in the algae but it was suggested they were the most bioactive.

They also found the extracts had a more powerful anti-cancer effect when used in combination than in isolation.

CVE was composed almost entirely of lutein and found to be 2.5 less effective at inducing apoptosis than CEE – made up of zeaxanthin along with violaxanthin and antheraxanthin.

“These results indicate that bioactive xanthophylls of C. ellipsoidea might be useful functional ingredients in the prevention of human cancers,” the researchers wrote.

But they noted both extracts were effective in battling colon cancer.

These semi-purified extracts of CEE and CVE both inhibited the growth of HCT116 (the colon cancer cells) in a dose-dependent manner,” they said.

“Considerable evidence supports the theory that some carotenoids, such as β-carotene and lycopene, may interfere with cancer-related molecular pathways and change the expression of many proteins involved in apoptosis.”

Method

The researchers obtained the extracts from a range of suppliers, which were washed, freeze-dried and refrigerated before being added to solutions and applied to the colon cancer sample cells.

HPLC analysis was used as well as a hemocytometer to give a cancer cell count. Both of the selected algaes were typical with a diameter of less than 10μm.

“After 24 hours of incubation, apoptotic cells began to lift from the surface monolayer, forming assorted sizes of spherical shapes,” the researchers wrote. “Apoptotic cells were more obviously apparent after treatment with CEE and CVE in concentrations of 80 μg/mL.”

The researchers called for additional study: “Further research to isolate active xanthophylls and to verify molecular mechanisms will be required to clarify fully the value of these effective constituents to cancer therapy.”

Other research

In regard to cancer, the Korean researchers noted a recent study (Wu, L. et al. “Antioxidant and antiproliferative activities of Spirulina and Chlorella water extracts”. J. Agric. Food Chem. 2005, 53, 4207–4212) that found spirulina extracts inhibited liver cancer cell growth whereas chlorella extracts produced only a minor result.

They suggested this may have been the case because of “variations in the extraction solvent”. That study had used water extraction, whereas the current research employed organic solvents.

Another recent study (Chew, B. P. et al. “Dietary lutein inhibits mouse mammary tumor growth by regulating angiogenesis and apoptosis”. Anticancer Res. 2003, 23, 3333–3339.) demonstrated lutein could inhibit growth in mouse mammary tumors by regulating angiogenesis and apoptosis.

Source: Journal of Agriculture and Food Chemistry

Web release date: October 23

“Antiproliferative Effects of Carotenoids Extracted from Chlorella ellipsoidea and Chlorella vulgaris on Human Colon Cancer Cells”

Authors: Kwang Hyun Cha, Song Yi Koo and Dong-Un Lee

Related products

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Fytexia
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Indena
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Capsugel
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Ingredion
Balancing Innovation and Risk in Sports Nutrition Ingredients
NSF-International
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Roquette
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars