Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news



Mulberry extract may prevent diabetes - study

By Stephen Daniells , 18-Jun-2007

A new mulberry powder, rich in a compound that inhibits the digestion of carbohydrates, may have the potential to prevent diabetes, suggests a new study from Japan.

Writing in the Journal of Agricultural and Food Chemistry, the researchers describe the production of a food-grade mulberry powder with an optimized content of 1-deoxynojirimycin (DNJ) content, a compound shown to inhibit the action of the glucosidase enzyme that controls the digestion of carbohydrates. "This study suggests that the newly developed DNJ-enriched powder can be used as a dietary supplement for preventing diabetes mellitus," wrote lead author Toshiyuki Kimura from Tohoku University, in collaboration with researchers from National Agricultural Research Center for Tohoku Region, Minato Pharmaceutical Company, and Nippon Medical School. An estimated 19 million people are affected by diabetes in the EU 25, equal to four per cent of the total population. This figure is projected to increase to 26 million by 2030. In the US, there are over 20 million people with diabetes, equal to seven per cent of the population. The total costs are thought to be as much as $132bn, with $92bn being direct costs from medication, according to 2002 American Diabetes Association figures. While DNJ has been shown to inhibit glucosidase, the concentration of the compound in commercial mulberry products is extremely low, state the researchers, with levels as low as about 0.1 per cent. Kimura and co-workers set about producing a food-grade mulberry powder with high DNJ content, and then determining the optimal dose of the DNJ-enriched powder needed to suppress blood glucose levels after a meal through clinical trials. Using hydrophilic interaction chromatography with evaporative light scattering detection the researchers obtained a mulberry powder containing 1.5 per cent DNJ. "Young mulberry leaves taken from the top part of the branches in summer contained the highest amount of DNJ," wrote the authors. To test the efficacy of the extract, the researchers recruited health volunteers and assigned them to receive 0, 0.4, 0.8, and 1.2 g of DNJ-enriched powder, giving a corresponding dose of DNJ of 0, 6, 12, and 18 mg. This was followed by 50 g of sucrose. Blood glucose and insulin levels were measured before sucrose consumption, and again 30-180 minutes later. "A human study indicated that the single oral administration of 0.8 and 1.2 g of DNJ-enriched powder significantly suppressed the elevation of postprandial blood glucose and secretion of insulin, revealing the physiological impact of mulberry DNJ (effective dose and efficacy in humans)," concluded the researchers. Further research is needed to examine the efficacy of the extract in other population groups, including overweight and obese subjects who are more susceptible to type-2 diabetes. The research adds to a growing body of evidence of the potential health benefits of berries that has filtered through to the consumers and has seen demand increase. Indeed, sales of blueberries, for example, are reported to have rocketed by 130 per cent, raspberry sales are said to have grown by 62 per cent in the last two years, a strawberry sales in the UK are reported to have increased by 34 per cent during the last two years. Source: Journal of Agricultural and Food Chemistry Published in ASAP Article 10.1021/jf062680g S0021-8561(06)02680-X "Food-Grade Mulberry Powder Enriched with 1-Deoxynojirimycin Suppresses the Elevation of Postprandial Blood Glucose in Humans" Authors: T. Kimura, K. Nakagawa, H. Kubota, Y. Kojima, Y. Goto, K. Yamagishi, S. Oita, S. Oikawa, and T. Miyazawa

Related products

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Balancing Innovation and Risk in Sports Nutrition Ingredients
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars