SUBSCRIBE

Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news

 

 

Natural extracts show obesity fighting potential: Rat study

By Nathan Gray , 15-Feb-2012

Four natural plant extracts recently identified by laboratory assays, and tested in rats, could help fight obesity, suggest researchers.

Scientists from the University of Granada, Spain, identified the four plant extracts that could help in preventing and fighting obesity through a series of in vitro tests on potential fat fighting compounds.

 

The most effective extracts in the test-tube were subsequently tested for their anti-obesity potential in rats.

 

The authors, led by Belén San Román Arenas, from the Biosearch Life Department of Research at Granada, said that whilst the results from their investigation are promising, further studies on animals are required to evaluate and confirm the anti-obesity effects of the extracts. They explained that once the effects are confirmed in animals, the extracts will then be tested on humans.

 

Román Arenas said the extracts selected in the study come from vegetables commonly consumed by humans, and can be used as nutritional supplements or added to food without problems, “once their effectiveness is tested and verified on humans.”

 

Study details

 

The researchers said that their research revealed that two of the extracts - which name cannot be disclosed for confidentiality reasons - inhibited the activity of an enzyme that is important in the breakdown of dietary lipids. As such the extracts were shown to reduce lipid absorption.

 

In addition, the assays uncovered two further extracts, which were found to induce the breakdown ​​of triglycerides accumulated within fat cells – thus reducing their fat content.

 

The researchers reported that rats fed with a fat-rich diet supplemented with the extracts that demonstrated potential in blocking fat absorption showed a 6-8% increase in the fat excreted in feces – compared to rats fed with a fat-rich diet without any supplementary extract.

 

They added that obese rats administered the two potentially fat reducing extracts were found to have lower fat cell contents after ten weeks.

 

“Lipid concentrations in plasma improved as did the parameters associated with the metabolism of glucose -which is related with diabetes and obesity,” said the researchers.

 

Román Arenas revealed that dietary administration of one of the extracts to obese rats “significantly reduced triglyceride and cholesterol levels in plasma by 67 and 49% respectively” – compared to a control group of obese rats that received no extracts. Glucose and insulin levels in plasma were also significantly improved, they reported.

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Fytexia
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Indena
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Capsugel
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Ingredion
Balancing Innovation and Risk in Sports Nutrition Ingredients
NSF-International
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Roquette
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars