Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news



Orange peel extract could fight skin cancer


Perillyl alcohol (PEOH), found naturally in mint and citrus fruits and also used as a food additive, is a powerful inhibitor of both UVB-induced non-melanoma and melanoma, reported researchers this week.

The compound has already been shown to inhibit the growth of many cancers and pre-cancerous lesions either by helping to fight cancer-causing chemicals or by interfering with signals that cause rapid cell division.

Speaking at the Frontiers in Cancer Prevention Research meeting in the US this week, Dr Janine Einspahr from the Arizona Cancer Center in Tucson, said: "Our research has documented that perillyl alcohol is a potent in vivo inhibitor of both UVB-induced non-melanoma and melanoma in a transgenic animal model."

"We are confident that further research will garner results that support these findings in human models," she added.

Phase I and Phase II studies of topically-administered perillyl alcohol are currently underway at the Arizona Cancer Center.

In the study, human keratinocytes (skin cells) were treated for 24 hours with 0.43 millimolars of PEOH, followed by exposure to 250 millijoules per cm2 of ultraviolet B radiation (UVB). Compared to untreated cells, expression of 5,533 genes was altered more than two-fold with UVB, and 5,837 genes with UVB and PEOH.

Skin cancer is the most common cancer in the US, with more than 1.3 million new cases expected in 2003. It is also increasing in Europe and among people under 35, it is the third most common cancer in women and fifth most common in men.

Other studies presented at the meeting highlighted the preventive effects of pomegranate extract and resveratrol on skin cancer.

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Balancing Innovation and Risk in Sports Nutrition Ingredients
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars