SUBSCRIBE

Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news

 

 

Quercetin may support lung health for smokers

1 commentBy Stephen Daniells , 11-Oct-2012

Quercetin may support lung health for smokers

Increased intakes of quercetin, a compound found in fruit and vegetables, may change the expression of genetic material in the lung function of smokers and reduce the risk of lung cancer, report researchers from Yale and the National Institute of Health (NIH).

Data published in Cancer Epidemiology, Biomarkers & Prevention found that frequent consumption of quercetin-rich food was associated with expression of a known tumor suppressor.

“Our findings provide suggestive insights into a possible mechanism to explain the inverse association between quercetin-rich food consumption and lung cancer risk observed in epidemiological studies,” wrote researchers led by NIH’s Maria Teresa Landi, MD, PhD.

Apples and onions

The study adds to the steadily growing body of science supporting the potential benefits of quercetin, a flavonoid found in fruits and vegetables. Potential health benefits include lowering of inflammatory markers, cholesterol reduction, and improving blood pressure.

However, many of these potential benefits are the result of in vitro or animal studies and data from human studies is rare.

One such human study by researchers from the University of Utah did indicate that a daily 730 milligram supplement of quercetin led to significant reductions in blood pressure.

The study, said to be the first to report the blood pressure-lowering activity of this flavonol, was published in the Journal of Nutrition (Nov. 2007, Vol. 137, pp. 2405-2411).

Cancer risk reduction

The new study indicates that cancer risk reduction may also be added to the list of potential benefits. The NIH and Yale researchers analyzed the expression of microRNA in people with lung cancer. MicroRNAs are short, single-stranded RNAs involved in the expression of genes. Misregulated microRNAs are said to play a role in cancer development.

MicroRNA data was analyzed for 264 lung cancer cases and quercetin intakes were assessed using a food-frequency questionnaire.

Results showed that a “quercetin-rich diet differentiated miR expression profiles of the tumor suppressor let-7 family among adenocarcinomas”, said the researchers.

Data also showed that, among former and current smokers with adenocarcinoma, there was differences in the microRNA expression between people with the highest-and-lowest quercetin intakes.

“To our knowledge, the present study is the only investigation examining the association between dietary quercetin, at a habitual consumable level, and microRNA expression in lung tissues,” wrote the researchers.

“In addition to having both dietary information and microRNA expression data, this study included several variables that allowed tight control for potential confounders.

“This richness of epidemiologic data coupled with epigenetic data from human tissues permitted an integrative approach – making it possible to explore underlying mechanisms that may explain the protective effect of quercetin and lung cancer risk seen in observational studies.”

Source: Cancer Epidemiology, Biomarkers & Prevention
Published online ahead of print, doi: 10.1158/1055-9965.EPI-12-0745
“Influence of quercetin-rich food intake on microRNA expression in lung cancer tissues”
Authors: T.K. Lam, S. Shao, Y. Zhao, et al. 

1 comment (Comments are now closed)

health

very useful information delivery thanks for post.

Report abuse

Posted by hazel wilson
15 October 2012 | 12h462012-10-15T12:46:05Z

Related products

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Fytexia
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Indena
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Capsugel
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Ingredion
Balancing Innovation and Risk in Sports Nutrition Ingredients
NSF-International
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Roquette
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars