SUBSCRIBE

Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news

 

 

Resveratrol may help to protect against alcohol induced nerve damage, suggest researchers

21-Jan-2013
Last updated on 21-Jan-2013 at 15:48 GMT2013-01-21T15:48:45Z

Resveratrol may help to protect against alcohol induced nerve damage

Resveratrol could help to battle diseases characterised by damaged to nerve cells from alcohol, according to new lab findings.

The findings, published in Food and Chemical Toxicology , suggest that the plant polyphenol could help to protect nerve cells from becoming damaged or dying due to exposure to alcohol – opening up the possibility that the molecule (dubbed the red wine compound) could help to battle alcohol related degenerative diseases.

Led by Zhenzhong Li from the Shandong University School of Medicine, China, the research team examined whether resveratrol had any in vitro effect on the growth and development of nerve cells in a sample of embryonic nerve tissue that had been exposed to alcohol (ethanol).

“Clinical studies and research in animals have established that ethanol consumption results in damage to the central and peripheral nervous systems and causes many diseases associated with neuronal degeneration,” explained Li and colleagues.

“The data in the present study indicate that resveratrol protects embryonic dorsal root ganglion neurons from ethanol-induced cell toxicity, including cell apoptosis, reduced neurite outgrowth and cell migration.”

The research team said that their lab findings suggest that resveratrol and its derivative could be good candidates for the prevention and/or treatment of such degenerative conditions.

Study details

Li and colleagues noted that although the full mechanism behind ethanol-induced neurotoxicity is still unclear, oxidative stress is known to play an important role.

“Because resveratrol (Res) is attracting increased attention due to its antioxidative properties, we investigated the neuroprotective efficacy of Res in ethanol-treated embryonic dorsal root ganglion (DRG) neurons in vitro,” they explained.

The team used cell culture models to test how resveratrol influenced the degeneration of neurones when exposed to ethanol – finding that the polyphenol compound increased the number of extended nerve fibres and neurons that migrated from the DRG explants.

Resveratrol was found to protect DRG neurons from ethanol-induced cell apoptosis, and alleviate ethanol-induced oxidative/nitrosative stress.

“The data from the present study indicate that Res protects DRG neurons from ethanol-induced neurotoxicity,” said Li and colleagues.

“These neuroprotective effects are associated with the activation of AMPK and SIRT1 by Res as well as its antioxidative effect,” they said.

Source: Food and Chemical Toxicology
Published online ahead of print, doi: 10.1016/j.fct.2012.12.052
“Neuroprotective effects of resveratrol on embryonic dorsal root ganglion neurons with neurotoxicity induced by ethanol”
Authors: Hongtu Yuan, Weiwei Zhang, Hao Li, Cheng Chen, Huaxiang Liu, Zhenzhong Li

Related products

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Fytexia
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Indena
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Capsugel
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Ingredion
Balancing Innovation and Risk in Sports Nutrition Ingredients
NSF-International
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Roquette
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars