Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news



‘Hype and hope but also a dearth of evidence’ for vitamin D as an IBD therapy: Review


By Anna Bonar+

Last updated on 12-Dec-2014 at 14:17 GMT2014-12-12T14:17:50Z

Can any single nutrient contribute to multiple complex disease mechanisms and, ultimately, have potential to treat these diseases?
Can any single nutrient contribute to multiple complex disease mechanisms and, ultimately, have potential to treat these diseases?

Vitamin D may modify the immune response in people with inflammatory bowel disease (IBD), according to a review of evidence for vitamin D as a novel therapy for the condition. 

The review by Maria O’Sullivan from Trinity College Dublin looked at scientific evidence of a link between vitamin D and inflammation, with a focus on IBD.

The question she was trying to answer was : "Can any single nutrient contribute to multiple complex disease mechanisms and, ultimately, have potential to treat these diseases?"

“This topic continues to attract interest; there is indeed some unavoidable ‘hype’, some ‘hope’ or promise from emerging scientific data, but a dearth of evidence,” O'Sullivan said.

Effects in animal models

Epidemiological studies suggested that IBD had an increased incidence in northern latitudes, which suggested there might be a link with sunlight patterns and thus vitamin D levels. According to the review, there was also significant evidence supporting vitamin D’s anti-inflammatory effects in animal models of IBD.

She concluded that studies suggested that vitamin D status may be associated with initiation, progression and severity of IBD. Moreover, growing evidence supported vitamin D as a ‘beyond bone’ treatment in IDB.

This was however insufficient to influence clinical practice, O'Sullivan said. “To date, intervention studies of vitamin D treatment for IBD are few, and as yet provide insufficient evidence for translation to clinical practice.”

For future studies, it may be important to consider how vitamin D-specific and IBD-specific factors influence response to vitamin D treatment.” she added.

The results were presented last year at the winter meeting of the Nutrition Society in London. 


Source: Proceedings of the Nutrition Society

Published online ahead of print doi:10.1017/S0029665114001621

"Vitamin D as a novel therapy in inflammatory bowel disease: new hope or false dawn?"

Author: M. O’Sullivan

2 comments (Comments are now closed)

Vitamin D is NOT actually a vitamin at all

Vitamin D is a seco-steroid hormone and as such is not truly a vitamin in the recognised sense of the word. So YES, it could be a substance (not a nutrient) that can affect multiple, complex disease mechanisms, in the same way other hormones and steroids can.

Report abuse

Posted by Annette
17 December 2014 | 05h462014-12-17T05:46:16Z

Many studies have concluded that IBD is treated by Vitamin D

A typical recent study:
Vitamin D improves inflammatory bowel disease outcomes: Basic science and clinical review

Report abuse

Posted by Henry Lahore
13 December 2014 | 02h272014-12-13T02:27:02Z

Related products

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Balancing Innovation and Risk in Sports Nutrition Ingredients
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars