Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news



Vitamin D3 may cut fat mass, boost heart health markers

By Stephen Daniells , 24-Feb-2012
Last updated on 24-Feb-2012 at 18:09 GMT2012-02-24T18:09:35Z

Vitamin D3 may cut fat mass, boost heart health markers

Daily supplements of vitamin D3 may improve certain markers of heart health like HDL cholesterol, and lead to significant reductions in body fat mass in overweight and obese people, says a new study.

A daily dose of 1,000 International Units (25 micrograms) was also associated with increases in LDL cholesterol, but the data suggested that the form of LDL became ‘less atherogenic’, compared with the placebo group, Iranian researchers report in the peer-reviewed British Journal of Nutrition.

Supplements of the sunshine vitamin were also associated with a significant reduction in body fat mass, compared with placebo, added researchers from the Tehran University of Medical Sciences.

“Although vitamin D3 supplementation significantly increased 25(OH)D concentrations, some participants in the vitamin D group did not reach sufficient 25(OH)D concentrations,” they wrote.

“It seems that they may need higher doses or a longer period of time to be supplemented.”

Sunshine vitamin

Vitamin D refers to two biologically inactive precursors - D3, also known as cholecalciferol, and D2, also known as ergocalciferol. Both D3 and D2 precursors are transformed in the liver and kidneys into 25- hydroxyvitamin D (25(OH)D), the non-active 'storage' form, and 1,25-dihydroxyvitamin D (1,25(OH)2D), the biologically active form that is tightly controlled by the body.

While our bodies do manufacture vitamin D on exposure to sunshine, the levels in some northern countries are so weak during the winter months that our body makes no vitamin D at all, meaning that dietary supplements and fortified foods are seen by many as the best way to boost intakes of vitamin D.

Vitamin D deficiency in adults is reported to precipitate or exacerbate osteopenia, osteoporosis, muscle weakness, fractures, common cancers, autoimmune diseases, infectious diseases and cardiovascular diseases. There is also some evidence that the vitamin may reduce the incidence of several types of cancer and type-1 and -2 diabetes.

Study details

The Tehran-based researchers recruited 77 overweight and obese women with an average age of 38 and randomly assigned them to receive either the daily vitamin D3 supplements or placebo for 12 weeks.

Data showed that HDL cholesterol levels increased in the vitamin D group, but decreased in the placebo group. LDL-cholesterol levels displayed the same trend in the groups, said the researchers, with increases observed in the vitamin group.

However, an increase was observed in the ratio of LDL to ApoB, the main apolipoprotein of LDL cholesterol that is responsible for the transport of cholesterol to tissues.

This result “indicates less atherogenic properties of LDL-cholesterol particles, whereas this ratio declined in the placebo group indicating that LDL-cholesterol particles were smaller and had higher density,” explained the researchers.

“The present study is one of the first reports about the effect of vitamin D3 supplementation solely on blood lipids and lipoproteins in healthy overweight and obese women,” they added.

“The present study has shown that although the daily intake of a 25 micrograms vitamin D3 supplement increases total and LDL-cholesterol concentrations, it has a beneficial effect on HDL-cholesterol, apoA-I concentrations, apoA-I:apo B-100 and LDL-cholesterol:apoB-100 ratios in overweight and obese women.”

Source: British Journal of Nutrition
Published online ahead of print, FirstView Article, doi: 10.1017/S0007114512000098
“Vitamin D3 and the risk of CVD in overweight and obese women: a randomised controlled trial”
Authors: A. Salehpour, F. Shidfar, F. Hosseinpanah

Related products

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Balancing Innovation and Risk in Sports Nutrition Ingredients
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars