Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news



Fish oil plus sterols and B vitamin may improve heart disease risk factors: Pilot study

By Nathan Gray+

Last updated on 11-Jan-2013 at 17:42 GMT2013-01-11T17:42:55Z

Plant streol, fish oil and B vitamins may help cut heart disease risk

A mixture of B vitamins, fish oils and plant sterols shows promise in boosting heart health by improving the lipid profile of young people with high levels of cholesterol, according to new research.  

The pilot study – published in Nutrition Journal – investigated the effects of a combination of plant sterols, fish oil and B vitamins on the levels of four independent risk factors for cardiovascular disease(CVD); LDL-cholesterol, triacylglycerols, C-reactive protein and homocysteine.

Led by Professor Zdeňka Ďuračková from Comenius University in Slovakia – in partnership with researchers from Obsidian Research Ltd, UK – the team behind the study found that the emulsified combination of B vitamins, plant sterols, and fish oil improved the lipid profile of children and adolescents with high levels of cholesterol.

“The present study shows that the combination of plant sterol esters (1300 mg), fish oil (1000mg EPA+DHA) and B vitamins impacts on LDL-cholesterol and homocysteine levels,” said the research team.

“To our knowledge, this is the first report of the use of the combination of these natural compounds for early dietary management of potential CVD risk.”

Ďuračková and her colleagues said the results if the study are ‘encouraging’ but added that they now need to be confirmed with a large randomised placebo controlled study.

Study details

The team recruited 25 participants, who were given the mixture once per day daily for a period of 16 weeks.

The emulsified preparation comprised of plant sterols esters (1300 mg), fish oil (providing 1000 mg eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA)) and vitamins B12 (50 mug), B6 (2.5 mg), folic acid (800 mug) and coenzyme Q10 (3 mg)

The research team found serum total cholesterol, LDL- cholesterol, VLDL-cholesterol, subfractions LDL-2, IDL-1, IDL-2 and plasma homocysteine levels were all significantly reduced at the end of the intervention period.

Triacylglycerols levels were reported to decrease by 17.6%, however this finding was not statistically significant, they said.

Ďuračková and her colleagues found no significant alterations in high sensitive C-reactive protein, HDL-cholesterol and apolipoprotein A-1.

“Daily intake of a combination of plant sterols, fish oil and B vitamins may modulate the lipid profile of hypercholesterolemic children and adolescents,” the authors concluded.

Source: Nutrition Journal
Published online ahead of print, doi: 10.1186/1475-2891-12-7
“Effect of a plant sterol, fish oil and B vitamin combination on cardiovascular risk factors in hypercholesterolemic children and adolescents: a pilot study”
Authors: Iveta Garaiova, Jana Muchová, Zuzana Nagyová, et al

Related products

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Balancing Innovation and Risk in Sports Nutrition Ingredients
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars