Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news



Liquorice root found to contain potentially anti-diabetic substance

By Nathan Gray , 17-Apr-2012
Last updated on 18-Apr-2012 at 11:30 GMT2012-04-18T11:30:07Z

Liquorice root found to contain potentially anti-diabetic substance

Amorfrutins found in the root of liquorice may have anti-inflammatory effects and could aslo be useful in the reduction of blood sugar levels, according to new research.

The study – published in the Proceedings of the National Academy of Sciences (PNAS) – reports that compounds isolated from liquorice roots could have benefits for treating symptoms of diabetes.

The substances, which have a simple chemical structure, are not only found in liquorice root, but are also in the fruit of the Amorpha fruticosa bush – from which the potentially anti-diabetic compound derives its name.

“The health-beneficial effects are based on the fact that the amorfrutin molecules dock directly onto a receptor in the nucleus called PPAR-gamma,” explained Dr Sascha Sauer, who led the research project. The expert noted that PPAR-gamma plays an important role in fat and glucose metabolism.

“The binding of the amorfrutin molecules activates various genes that reduce the plasma concentration of certain fatty acids and glucose,” he said. “The reduced glucose level prevents the development of insulin resistance – the main cause of adult diabetes.”

However, the expert said that drinking liquorice tea or eating liquorice candy will not help to treat diabetes: “The concentration of the substances in the tea and liquorice is far too low to be effective.”

The team have therefore developed a special extraction processes to help obtain the amorfrutins from the plant in sufficient concentrations. They said the process could be used to produce amorfrutin extracts on an industrial scale.

“The amorfrutins can be used as functional nutritional supplements or as mild remedies that are individually tailored to the patient,” said Sauer.

“In view of the rapid spread of metabolic diseases like diabetes, it is intended to develop these substances further so that they can be used on humans in the future,” he added.

Source: PNAS
Published online ahead of print, doi: 10.1073/pnas.1116971109
“Amorfrutins are potent antidiabetic dietary natural products”
Authors: C. Weidner, J.C. de Groot, A. Prasad, A. Freiwald, C. Quedenau

Related products

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Balancing Innovation and Risk in Sports Nutrition Ingredients
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars