SUBSCRIBE

Breaking News on Supplements, Health & Nutrition - Europe US edition | APAC edition

News > Research

Read more breaking news

 

 

Milk protein may offer cancer protection: Study

04-Oct-2012
Last updated on 05-Oct-2012 at 12:24 GMT2012-10-05T12:24:10Z

Milk protein may offer cancer protection

The milk proteins may have anti-cancer properties, say researchers, after new in vitro tests reveal the cancer fighting potential of lactoferricin4-14.

The study – published in the Journal of Dairy Science – tested the effects of the milk protein lactoferricin4-14 (Lfcin4-14) on measures of DNA damage in lab tests that exposed colon cancer cells to ultraviolet (UV) light.

Led by Professor Stina Oredsson from the University of Lund, Sweden, the researchers found that the milk protein significantly reduced the growth rate of the cancer cells over time by extending certain parts of the cell cycle.  

In addition the researchers found that Lfcin4-14 reduced DNA damage in the cancer cells – a finding which the team believes could have applications for non-cancer cells too.

“We found that Lfcin4–14 treatment resulted in decreased DNA strand breaks in UV light-irradiated Caco-2 cells,” said the researchers. “We believe that this observation is of importance for normal cells and the possibility of Lfcin4–14 being part of the cancer preventive effect of milk.”

To understand the mechanisms behind the reduction in DNA strand breaks the team also monitored the expression of key proteins involved in cell cycle control, DNA repair, and cell death. They found an increase in certain proteins associated with DNA repair in addition to decreases in proteins associated with cell death.

“These changes in expression support our hypothesis that Lfcin4-14 treatment resulted in increased DNA repair," says Dr. Oredsson.

Source: Journal of Dairy Science
Volume 95, Issue 10 , Pages 5552–5560, doi: 10.3168/jds.2011-5279
“Reduction of ultraviolet light-induced DNA damage in human colon cancer cells treated with a lactoferrin-derived peptide”
Authors: C. Freiburghaus, H. Lindmark-Månsson, M. Paulsson, S. Oredsson

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Fytexia
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Indena
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Capsugel
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Ingredion
Balancing Innovation and Risk in Sports Nutrition Ingredients
NSF-International
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Roquette
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars