Science short

Resveratrol’s inflammatory potential boosts bone health in obese men: Study

By Shane STARLING contact

- Last updated on GMT

Resveratrol study demonstrates bone benefits
Resveratrol study demonstrates bone benefits

Related tags: Resveratrol, Bone

Resveratrol boosts bone health by stimulating mineralisation and bone formation, a study among 74 middle-aged, obese men has found.

The gold standard double blind, randomised, placebo-controlled research was conducted in Denmark at Aarhus University Hospital gave the men with an average age of 49 and body mass index (BMI) of 33.7 either 1000mg, 150g or placebo daily via supplements.

The primary endpoint was change in bone alkaline phosphatase(BAP) and this measure improved significantly over 16-week study compared to placebo.

“The increase in bone formation and/or mineralisation could explain the temporary decrease in serum levels of ionised calcium, due to calcium deposition in the bone and this decrease in calcium would tend to stimulate PTH secretion and thereby counteract the expected decrease in PTH with increasing vitamin D,”​ the researchers speculated.

redwinesplash-3x2

Resveratrol is a powerful polyphenol and anti-fungal chemical that is often touted as the bioactive compound in grapes and red wine. Interest in the compound exploded in 2003 when research from David Sinclair and his team from Harvard reported that resveratrol was able to increase the lifespan of yeast cells.

According to Sinclair’s findings, resveratrol could activate a gene called sirtuin1 (Sirt1 – the yeast equivalent was Sir2), which is also activated during calorie restriction in various species, including monkeys.

Other studies with only resveratrol have reported other benefits, including supporting heart health, blood sugar management, and energy endurance enhancement.

“To gain better insight, future studies should include double-labeled bone biopsies useful to determine for example mineral apposition rate and to quantify osteoclasts by tartrate-resistant acid phosphatase (TRAP) staining,​the researchers said.

 

Source:

The Journal of Clinical Endocrinology & Metabolism

October 2014 (DOI: http://dx.doi.org/10.1210/jc.2014-2799​)

Resveratrol Increases Bone Mineral Density and Bone Alkaline Phosphatase in Obese Men: A Randomized Placebo-Controlled Trial​’

Authors: Marie Juul Ornstrup, Torben Harsløf, Thomas Nordstrøm Kjær, Bente Lomholt Langdahl, Steen Bønløkke Pedersen

Related news

Show more

Related products

show more

eldosamb® the ingredient for immune power

eldosamb® the ingredient for immune power

Anklam Extrakt GmbH | 25-Oct-2021 | Technical / White Paper

eldosamb®, an anthocyanin-enriched elderberry extract, revealed its excellent potential as ingredient for immune health products. The preclinical research...

Children’s Bones Need Vitamins K2 & D3

Children’s Bones Need Vitamins K2 & D3

NattoPharma – Gnosis by Lesaffre | 27-Sep-2021 | Data Sheet

Childhood is a crucial period for developing healthy bone mass. However, research shows children have 8-10x higher levels of inactive osteocalcin, which...

Plant-based Proteins Collection from Ingredients4U

Plant-based Proteins Collection from Ingredients4U

Ingredients4u AG | 27-Sep-2021 | Technical / White Paper

Plant-based products have always been a hot topic in the market, the plant-based food market was valued at $29.4 billion in 2020. Ingredients4U is one...

Related suppliers

Follow us

Products

View more

Webinars