Could faecal microbiota transplantation be used to tackle asthma?

By Will Chu

- Last updated on GMT

©iStock/Bubutu
©iStock/Bubutu

Related tags: Gut microbiota, Bacteria, Inflammation, Gut flora, Asthma

Faecal microbiota transplantation is arguably more effective in managing asthma than current treatments and even probiotics, say two scientists, who call for more research into its use.

In an opinion piece, the team identify faecal microbiota transplantation (FMT) as a ‘natural’ treatment that directly addresses the chronic inflammation associated with the condition.

Its inexpensive implementation is another plus point as the scientists point to an imbalance within the gut microbiota that brings on the onset of asthma – a condition that it is predicted to increase by 100 million people by 2025.

Drs Yongbo Kang and Yue Cai from Kunming University of Science and Technology in China stated the case for FMT since “a faecal infusion overcomes the intrinsic quantitative gap of probiotics”.

“Oral probiotic doses are usually more than three orders of magnitude lower than the 100 trillion native micro-organisms of the large bowel,”​ they added.

“In addition, the administration of faecal flora establishes a durable alteration of the recipient's gut microbiota, while probiotics are able to colonise the gut lumen only for a temporary period.”

FMT can play a major role in addressing the inflammatory immune response that characterises conditions such as diabetes, inflammatory bowel disease (IBD) and autoimmune diseases as well as proving efficacious in recurrent bacterial infections.

Environmental factors in asthma onset

Suggestions that genetic factors are only partially responsible for the risk of developing asthma has led to questions as to how environmental factors fit into disease onset and progression.

This theory gains credence as asthma often begins in early childhood, when the gut microbiota is primarily developed.

“Careful RNA gene sequencing showed that the patient's stool was strikingly similar to the donor stool after transplant suggesting that the donor's stool had helped restore a healthy colonic microbiome,” ​the team highlighted.

“Accounting our microbial flora as a bodily organ ​let the interpretation of FMT change from being considered a mere injection of faeces to becoming a true organ transplantation.”

FMT is only just coming to the forefront as a realistic approach in the management of asthma and other conditions.

Available data in this field remain limited and recent technological developments permit the identification of microbes and their products using culture-independent molecular detection techniques.

Faecal biobanks

The concept of faecal biobanks in which faecal matter is collected and stored ready for transplantation into a new host has been mooted for some time now with Europe in particular taking a lead in its conception and implementation.

In addition to the Stool Bank East based in Leiden, Netherlands, the Taymount Clinic (Hitchin, UK) have started banking patients' own stool for future medical use.

The US has also made gains in this field with biobanks forming part of the OpenBiome project, located in Massachusetts, US along with AdvancingBio (Mather, CA, USA), and Melbourne FMT based in Australia.

Source: Allergologia et Immunopathologia
Published online ahead of print, doi: 10.1016/j.aller.2017.04.008
“Future prospect of faecal microbiota transplantation as a potential therapy in asthma.”
Authors: Y Kang. Y Cai.

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1 comment

What is asthma and how can it be treated successfully?

Posted by Dr. Johann Menser,

In asthmatics, the mucous membranes of the airways are constantly inflamed. The bronchia react to a variety of substances which are actually harmless, with a violent defense reaction. Asthma is therefore an allergy. A person with an intact immune system does not get any asthma.
The Science Center of the Dayeng Foundation, in collaboration with other international scientists, has been researching the biology and especially the immune system of humans for more than 30 years. The research results were clear. Asthma develops exclusively in industrialized countries and the cause is a disturbed or weak immune system.
The Research Center of the Dayeng Foundation has succeeded in repairing the immune system of humans. In 2001 a special therapy center was established. Since that time, people are treated whose immune system is weakened. The successes in the treatment of asthma patients are almost 100%. The treated patients can now lead a normal life again. More information here: http://lupus-trust.net
Dr. Johann Menser
Attending Doctor of the Therapy Center of the Dayeng Foundation, independent science center

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