Beetroot juice may help heart failure patients keep exercising

By Tim Cutcliffe contact

- Last updated on GMT

© iStock/ kostman
© iStock/ kostman

Related tags: Beetroot juice, Heart failure

Beetroot juice supplements could improve exercise capacity in some patients with heart failure, new research suggests.

According to the research, published in the Journal of Cardiac Failure​, around half of all heart failure cases suffer reduced ejection fraction (rEF), a condition in which heart muscle contraction is ineffective, preventing enough oxygen-rich blood from reaching the body.

Patients in this small proof-of-concept study who were given dietary nitrate in the form of beetroot juice saw significant increases in exercise duration, peak power and also peak oxygen intake (VO­­­2​ peak), compared with placebo.   

No accompanying changes in breathing response (ventilatory demand) or exercise efficiency occurred, noted the research team, a collaboration between Washington University School of Medicine, St. Louis, Missouri and Indiana University Purdue University Indianapolis (IUPUI).

“The results of this proof-of-concept study demonstrate that acute ingestion of nitrate (in the form of a concentrated beetroot juice supplement) increases aerobic exercise performance and VO2peak, but does not alter ventilatory responses or gross or delta efficiency during exercise, in patients with mild-to-moderate HFrEF,”​ commented first author Professor Andrew Coggan at IUPUI.


"Abnormalities in aerobic exercise responses play a major role in the disability, loss of independence and reduced quality of life that accompany heart failure,"​ explained Coggan.

 "Perhaps more importantly, elevations in ventilatory demand and decreases in peak oxygen uptake are highly predictive of mortality in patients with heart failure."

If findings are replicated in larger trials, beetroot juice might be used in interventions to improve quality of life, and possibly lengthen the lives of patients with HErEF, the researchers suggested.

“Larger (i.e. multicentre) trials are needed to confirm the present findings and to determine whether longer term dietary NO3 − treatment improves physical activity levels, quality of life, and perhaps even survival in patients with HFrEF,”​ said Coggan.

No side effects

Another important outcome from the trial was the lack of harmful side effects from the beetroot juice.

"In this case, lack of any significant changes is good news,"​ Said Coggan.

However, the effectiveness of the treatment may depend on the ability to convert nitrate (and nitrite) to the active metabolite nitric oxide.   Therefore, the researchers excluded patients taking proton pump inhibitor and other ant-acid medications, as low stomach-acid conditions are known to impair this conversion capability.

Study details

The study was a randomised placebo-controlled, crossover type with a one-week washout period. Ten people were enrolled originally, although only eight completed the trial.

The subjects were given either 140 millilitres of beetroot juice (Beet It, manufactured by James White Drinks, UK) or placebo. Interestingly, the placebo was specially produced by the same manufacturer, who extracted the nitrate from the beetroot juice using an ion exchange resin. The placebo was therefore indistinguishable from the active product in packaging, taste, smell, colour and texture.

Scientists measured blood nitrate and nitrite and also breath nitric oxide levels at baseline and two hours after consuming the beetroot juice or placebo. Heart rate and blood pressure measurements weretaken before, during and after exercise. The researchers also measured perceived exertion just prior to the end of each stage.

The exercise consisted of steady state pedalling on a cycle ergometer below peak exertion, after which intensity was gradually increased until the participants no longer wished to continue.

Source:  Journal of Cardiac Failure
Volume 24, Issue 2, pages 65-73, doi: 10.1016/j.cardfail.2017.09.004
“Dietary Nitrate Increases VO2peak and Performance but Does Not Alter Ventilation or Efficiency in Patients With Heart Failure With Reduced Ejection Fraction”
 Authors:  Andrew R. Coggan  et al

Related news

Related products

show more

Water dispersible phytosterols by Lipofoods

Water dispersible phytosterols by Lipofoods

Lipofoods, a Lubrizol Company | 21-Mar-2018 | Product Presentation

The cholesterol lowering effect of plant sterols is well-documented in literature. Due to their insolubility in water and lipids, the incorporation of...

The Modern Athlete, Concepts & Formulations

The Modern Athlete, Concepts & Formulations

Sabinsa Corporation | 26-Feb-2018 | Data Sheet

Today sports nutrition is one of the most promising sectors of the dietary supplement industry. Evolving from an “athletes only” category to include people...

Are you a 40 + Man?

Are you a 40 + Man?

Chemical Resources (CHERESO) | 05-Feb-2018 | Data Sheet

Urinary problems like frequency, dribbling are common among men above 40. Prosman is a natural, clinically evaluated and patented ingredient for the management...

Related suppliers

Follow us

Featured Events

View more


View more