Vitamin E tocotrienol shows brain protection promise

By Jess Halliday

- Last updated on GMT

Related tags: Nervous system, Brain

The natural vitamin E alpha-tocotrienol (TCT) may protect the brain
against stroke- and glutamate-induced degeneration, according to
researchers in a new animal study.

Researchers from Ohio State University Medical Center decided to carry out a rat study following the successful results of an earlier trial, in which lead investigator Professor Chandan Sen demonstrated that unlike alpha-tocopherol (TCP), a better-known form of vitamin E, TCT blocks glutamate-induced cell death. Glutamate-induced toxicity is understood to contribute to pathological cell death in the nervous system.

In the new study, published in the October issue of the American Heart Association journal Stroke​, Sen and his team studied the effects of low-dose TCT supplementation (Tocomin supplied by Carotech) on the brain tissue of spontaneously hypertensive rats after they experienced stroke. Hypertension is one of the main risk factors for stroke.

The supplemented rats were less susceptible to stroke-induced brain damage than unsupplemented control rats. The same low dose of TCP had no effect.

Vitamin E is a generic term for both tocopherol and tocotrienol derivatives. There are significant differences in their chemical structures which make them act very differently in humans. Of the two, tocopherol is the most commonly used, yet the antioxidant powers of tocotrienol have been proven to be much stronger than tocopherol.

The results were attributed to the suppression of c-Src, a molecular checkpoint associated with stroke. 12-Lox deficient mice were also seen to be more resistant to stroke-induced injury than wild-type controls, which led the researchers to believe that 12-lipoygenase is another TCT-sensitive checkpoint critical to neuron deaths.

"The natural vitamin E, TCT, acts on key molecular checkpoints to protect against glutamate- and stroke-induced neurodegeneration,"​ they concluded.

"Eighty-three years after the discovery of vitamin E in 1922, it is long overdue to closely examine all naturally occurring forms of vitamin E side by side,"​ said Professor Sen.

Sen was positive that the results of the new study and his previous investigations could prove useful in protecting against the debilitating effects of stroke, if TCT has the same protective effect on human brains:

"Attention to the naturally occurring tocotrienols, especially to their neuroprotective properties, could well provide us with a powerful tool to combat neurodegeneration especially stroke, by safe dietary means,"​ he said.

Related news

Show more

Related products

show more

WHERE THE WORLD IS GOING NEXT FOR VITAMIN D

WHERE THE WORLD IS GOING NEXT FOR VITAMIN D

PLT Health Solutions | 22-Jun-2022 | Product Brochure

Earthlight® Whole Food Vitamin D is a clean label ingredient that can help you create cutting-edge fortified foods and supplements. Low use levels mean...

Whitepaper: Optimizing immunity with vitamin D

Whitepaper: Optimizing immunity with vitamin D

DSM Nutritional Products | 16-Jun-2022 | Technical / White Paper

With vitamin D science evolving rapidly since the COVID-19 pandemic, our new whitepaper breaks down the latest research on the role of vitamin D in supporting...

Stronger Bones Begin with MenaQ7® Vitamin K2

Stronger Bones Begin with MenaQ7® Vitamin K2

Gnosis by Lesaffre | 06-Jun-2022 | Infographic

By activating the K-dependent protein Osteocalcin, Vitamin K2 as MK-7 enables the body to properly utilize calcium, binding it to the bone matrix.

Related suppliers

Follow us

Products

View more

Webinars