Rousselot builds bone health science behind collagen

By staff reporter

- Last updated on GMT

Related tags Osteoporosis Bone

A hydrolysed collagen ingredient may boost bone health and help reduce the risk of osteoporosis, says a new study from France.

A study with mice with their ovaries removed - used as a model for postmenopausal osteoporosis - found that the collagen was associated with an increase in the activity osteoblasts – cells responsible for cell formation.

Furthermore, the ingredient was associated with a decrease in activity of osteoclasts – cells responsible for bone resorption, report the researchers in the journal Bone​.

“The results of the present study indicate that hydrolyzed collagen modulates bone formation and mineralization of the bone matrix by stimulating osteoblast growth and differentiation while reducing osteoclast differentiation,”​ wrote the researchers, led by Fanny Guillerminet from France’s INRA.

“These effects led to growth of the external diameter of the cortical zone. These results could be of potential interest for nutritional intervention in the prevention of bone loss,”​ they added.

The study uses Rousselot’s Peptan branded ingredient, and the company supported the study.

The results require support from additional studies particularly in humans, may see the ingredient established in the bone health market.

Osteoporosis is estimated to affect about 75m people in Europe, the USA and Japan. According to the International Osteoporosis Foundation, the total direct cost of osteoporotic fractures is €31.7bn in Europe, and 17.5bn in the US (2002 figure). The total annual cost of osteoporosis in the UK alone is over £1.7bn (€2.5bn), equivalent to £5m (€7.3m) each day.

Study details

Guillerminet and her co-workers divided animals into three groups: One group acted as the control and did not have their ovaries removed; one group had their ovaries removed and consumed a normal diet; the final group was the same as the second except the diet was supplemented with Peptan, said the researchers.

After 12 weeks of study, no significant difference in bone mineral density between the control and Petpan-fed group was observed. However, a reduction in BMD in the ovariectomised animals not fed the hydrolysed collagen was observed.

A reduction in levels of a peptide called carboxy terminal telopeptide (CTX), a usual marker of bone resorption, were lower in the collagen-fed group, said the researchers.

“It is concluded that dietary hydrolyzed collagen increases osteoblast activity (as measured in primary tissue culture), which acts on bone remodeling and increases the external diameter of cortical areas of the femurs,”​ concluded the researchers.

Source: Bone
Published online ahead of print, doi:
“Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: An in vitro and in vivo study”
Authors: F. Guillerminet, H. Beaupied, V. Fabien-Soule, D. Tome, C-L. Benhamou, C. Roux, A. Blais

Related news

Show more

Related products

show more

Mobility Market: Discover New Trends & Innovation

Mobility Market: Discover New Trends & Innovation

Content provided by vaneeghen | 06-Sep-2023 | White Paper

The demand for joint health products is on the rise, branching out beyond age-related issues into active nutrition and prevention; driving new opportunities...

Full Vegan Protein Ingredients Solution

Full Vegan Protein Ingredients Solution

Content provided by Ingredients4u AG | 24-Jul-2023 | Product Brochure

Plant-based products have always been a hot topic in the market, the plant-based food market was valued at $29.4 billion in 2020.

Solutions of Amino Acids-Based Infant Formula

Solutions of Amino Acids-Based Infant Formula

Content provided by INNOBIO Corporation Limited | 22-Jun-2023 | White Paper

Many infants who are born with nutritional defects often need specifically developed infant formulas to maintain their growth and development. Amino acids-based...

Follow us


View more