Too much dietary manganese could cause staph heart infections, says study

By Emma Cash

- Last updated on GMT

A study has found that excessive consumption of dietary manganese could increase the risk of heart infection by the bacterium Staphylococcus aureus (staph).

Dietary manganese is an essential mineral found in leafy green vegetables, fruits and nuts.

According to the report, published in Cell Host & Microbe,​ people with excess levels of tissue manganese, including people who take dietary supplements with high concentrations of manganese, may be at risk for staph heart infection.

Staph heart infection is the leading cause of bacterial endocarditis – infection of the inner lining of the heart chamber and heart valves – as well as being the second most frequent cause of bloodstream infections.

‘Super-dosing’ should be considered carefully

Dr Eric Skaar, Ernest W. Goodpasture Professor of Pathology and senior author of the study, said that it shows people should be careful when taking excessive supplements.

“The human body does a wonderful job of regulating nutrient levels, and a traditional Western diet has plenty of minerals in it. The idea of super-dosing nutrients needs to be given careful consideration.”

The team used mice to study the effects of dietary manganese on the body.

Results showed that most mice that consumed excessive manganese – three times more than usual – died from staph infections.

“We know very little about how manganese is moved around and regulated. It’s a mystery why high manganese affects staph infection of a single organ,”​ Skaar said.

Furthermore, it was found that excessive consumption of the mineral inactivated defence mechanisms against pathogens.

Skaar explained that in usual circumstances, “neutrophils pour into the site of infection and blast the bacteria with reactive oxygen species”​ in response to staph infections.

However, the excess manganese stops this from happening.

“It’s striking that a single dietary change can inactivate one of the most powerful branches of innate immune defence and lead to fatal infection,” ​Skaar said.

Manganese also prohibits the protein calprotectin from carrying it out its usual protective duties.

Calprotectin acts as a sponge within the body and mops up excess manganese and other metals. However, calprotectin is ineffective in the high manganese hearts. Skaar said it is unknown why this happens.

Skaar and his team are continuing their research on manganese, particularly how it is transported and regulated.

Study: Dietary Manganese Promotes Staphylococcal Infection of the Heart

Source: Cell Host & Microbe

Published online, DOI: 10.1016/j.chom.2017.08.009

Authors: Lillian J. Juttukonda, Evelien T.M. Berends, Joseph P. Zackular, Jessica L. Moore, Matthew T. Stier, Yaofang Zhang, Jonathan E. Schmitz, William N. Beavers, Christiaan D. Wijers, Benjamin A. Gilston, Thomas E. Kehl-Fie, James Atkinson, Mary K. Washington, R. Stokes Peebles, Walter J. Chazin, Victor J. Torres, Richard M. Caprioli, Eric P. Skaar.

Related news

Show more

Related products

show more

Sweetening solution for active nutrition

Sweetening solution for active nutrition

Content provided by ADM | 19-Feb-2024 | Case Study

When you add GrainSweet® Liquid Maltodextrin to your active nutrition applications, you get the production efficiencies, clean labels, and clean tastes...

An Insights-driven Holistic Approach to Health

An Insights-driven Holistic Approach to Health

Content provided by Lipofoods, a Lubrizol Company | 25-Sep-2023 | Product Brochure

As they adopt the notion of holistic health, proactive consumers are driving the demand for products that have science-backed ingredients and offer sensory...

Golden Omega® Sustainability Strategy

Golden Omega® Sustainability Strategy

Content provided by LEHVOSS Nutrition | 11-Sep-2023 | Data Sheet

Commitment to sustainability at Golden Omega® is ever growing as they continue to put objectives in place to secure a better environment for the future....

Related suppliers

Follow us


View more