New curcumin and boswellia formulation demonstrates potent anti-inflammatory action
Following the success of NovaSOL Curcumin, the German company has created the new NovaSOL Curcumin/Boswellia formula which combines curcumin with Boswellic acids derived from the gum of the Boswellia serrata (a plant native to India).
Launched by IFF Health (formerly known as Frutarom Health) the new liquid proprietary formula is developed with the same NovaSOL micellation technology which serves as a 'nature-like' carrier system of minute particles by enabling ultrafine distribution of the herbs’ active components.
The formulation is both water- and lipid-soluble, and highly stable enabling it to be readily adapted into food and beverage applications. In addition, the concentrated golden liquid can be delivered is small and easily digested dosages.
The enhanced bioavailability of NovaSOL Curcumin was established in a human clinical trial in which there was an increase in bioavailability of up to 185-fold when compared to standard extracts.
Wouter Haazen, product manager of IFF Health, says: “The NovaSOL delivery system provides significant opportunities to truly optimize curcumin and boswellia’s synergetic properties to maximum effect.”
A mice study published last year in the journal Nutrition found that liquid, micellar curcumin, in combination with boswellia not only increased bioavailability of both compounds but also was associated with increased biological activity as compared to the compounds alone or a native mix of the herbs.
Adjuvant arthritis was induced by injecting Freund's complete adjuvant (FCA) into the right hind paw of rats and monitoring paw volume over 3 wk. The drugs were given daily for 3 weeks, starting from the day of adjuvant inoculation.
The serum was collected at end of the experiment for the assay of inflammatory and oxidative stress parameters and statistical comparisons between different groups were carried out.
Solubilized curcumin showed better antiinflammatory activity than its native form and the combination of curcumin and boswellia solubilisates synergistically produced an even more potent therapeutic effect.
Researchers noted: "Micellar curcumin, in particular in combination with micellar boswellia, may thus represent a promising concomitant tool for antiinflammatory treatment and a potential antiinflammatory alternative to synthetic drugs."