EFSA: ‘No link between Nestlé infant formula consumption and reduced dermatitis risk’

By Will Chu

- Last updated on GMT

©iStock
©iStock

Related tags: Nestlé, Efsa, Infant formula, protein hydrolysate

The European Food and Safety Authority (EFSA) has rejected claims a peptide blend included in infant formula could reduce the risk of developing atopic dermatitis.

EFSA’s Panel on Nutrition, Novel Foods and Food Allergens (NDA), concluded​ a cause-and-effect relationship could not be established between the formula’s consumption and a risk reduction in developing atopic dermatitis in infants with a family history of the allergy.

“The Panel notes that, among the 14 human intervention studies provided, no human intervention studies have been submitted from which conclusions could be drawn for the scientific substantiation of the effect.

“In the absence of evidence from human clinical studies on the effect of the infant formula in reducing the risk for developing atopic dermatitis, the Panel notes that the animal studies that were also submitted cannot be used for the scientific substantiation of the effect.”

Human intervention studies

Key to the Panel’s decision were three human intervention studies, one​ of which was described as a randomised, single-blinded (caregivers were aware of the group allocation) controlled trial.

The trial was carried out in infants with two atopic parents and who were either fed the formula under evaluation or a control formula manufactured from intact cow's milk protein.

Statistical analysis of the study results revealed the feeding of cow's milk formula showed higher odds for developing atopic dermatitis at one year of age.

However, the Panel noted that it is unclear to which feeding this was compared and whether exclusively breast-fed infants were part of this analysis or not.

“The Panel considers that, owing to the methodological limitations of this study and the associated analysis, i.e. single-blind study design, unclear randomisation procedure and unclear statistical analysis, no conclusion can be drawn from this study for the scientific substantiation of the effect.”

Manufacturing process

According to details given by Nestlé, the manufacturing process of the powdered infant formula would involve pre-heating the liquid hydrolysate and then mixed with free amino acids, minerals, vitamins, carbohydrates, oils and optionally nucleotides.

The blend is then heated again, evaporated, homogenised and evaporated again. Afterwards, additional ingredients are added before spray drying, as well as afterwards (dry-mixed with the powder) before sieving and final packing under protective atmosphere.

For liquid formula, which was also the subject of EFSA’s evaluation, after the addition of the last ingredients, the steps of the second heat treatment, evaporation and spray drying (applied in the case of the production of the powder) are replaced by sterilisation (ultra-high temperature treatment) before aseptic homogenisation, and aseptic filling.

The decision is the latest step in a regulatory process that started back in July 2019, where the technical dossier was first received by EFSA.

The scientific evaluation procedure, which started in January 2020 was suspended in February 2021 top be restarted on February 2021.

During the Panel’s meeting in April 2021, the NDA Panel, having evaluated the data, adopted its opinion on 29 April 2021.

Related news

Show more

Related products

show more

DurOmega® Algal DHA 20% water dispersible powder

DurOmega® Algal DHA 20% water dispersible powder

INNOBIO Corporation Limited | 30-May-2022 | Technical / White Paper

INNOBIO most recently launched a new product DurOmega® Algal DHA 20% water dispersible powder with significantly reduced fishy odor and taste, which optimizes...

Dermial®: nourishing innovation in skin and beauty

Dermial®: nourishing innovation in skin and beauty

BIOIBERICA, S.A.U. | 18-May-2022 | Technical / White Paper

Breathe life into your innovation pipeline with Dermial® – the first hyaluronic acid matrix ingredient of its kind. Its unique combination of three naturally-occurring...

Robertet Nutricosmetic’s offer driven by science

Robertet Nutricosmetic’s offer driven by science

ROBERTET - Food and Nutra | 09-May-2022 | Technical / White Paper

Deep research is the backbone of our portfolio. For 20 years, Robertet has been working on the development of its nutricosmetic range with its dedicated...

Protect your skin daily from U.V

Protect your skin daily from U.V

ROBERTET - Food and Nutra | 29-Apr-2022 | Technical / White Paper

Able to increase skin resistance to UV exposure and to fight both UVA and UVB associated side-effects, Holimel® is a new solution for daily skin protection...

Related suppliers

Follow us

Products

View more

Webinars