Researchers explore influence of grape consumption on gut microbiome

By Danielle Masterson

- Last updated on GMT

Getty Images / ninelittle
Getty Images / ninelittle

Related tags Grape Gut microbiome gut microbiota

The study suggests eating grapes can provide subtle gut modulation, with potential benefits for health.

A new human study explored the potential of grapes to modulate the human microbiome. The research, published in Scientific Reports, was carried out by several East coast scientists and funded in part by the California Table Grape Commission.

“Words such as 'prebiotic', 'probiotic', 'synbiotic', 'eubiosis' and 'dysbiosis' are now commonly incorporated in the ordinary lexicon of the lay public and scientific community,” the authors noted.

“Based on human clinical trials, or studies conducted with animal models, results have suggested an array of responses mediated by the grape on atherosclerosis, inflammation, cancer, gastrointestinal health, CNS effects, osteoarthritis, urinary bladder function, and vision."

With this in mind, the researchers conducted an eight-week human study analyzing the impact of grape (Vitis vinifera​ L.) consumption on the microbiome composition as well as urinary and plasma metabolites. 

“In the present study, the human subjects varied by gender and age, but all were deemed to be in good health. It was thereby expected these individuals began the study in a eubiotic state, i.e., with a balance between beneficial and harmful bacteria. Thus, our goal was not geared toward inducing any particular alteration. Our goal was simply to determine if consumption of a common dietary fruit, i.e., the grape, functioned as a prebiotic, probiotic, or antibiotic, or, in fact, led to no major change at all.”

Study details

Over the course of eight weeks, 29 healthy, free-living male and female subjects in their 20s to 50s were studied.

Following a two week period on a controlled dietary regimen, the diet was supplemented for a two-week period in which a well-defined grape surrogate equivalent to three normal servings (2 1/4 cups) were consumed on a daily basis. Lastly, a one month washout period was included where the controlled dietary regimen was continued but grape supplementation was discontinued.

The subjects’ microbiome composition as well as urinary and plasma metabolites were analyzed following two weeks of a restricted diet (day 15), two weeks of a restricted diet with grape consumption (day 30) and four weeks of restricted diet without grape consumption (day 60).


Changes were seen in the amounts of bacteria detected and in enzyme levels and biological pathways. The analysis of a subgroup of subjects showed unique patterns of microbe distribution.

“Our study showed that grapes actively impact the gut microbiome causing shifts in the intricate interactive networks and thus subtly changing the gut microbiome and the resulting chemicals it produces,” said John Pezzuto, lead author and professor and dean at Western New England University College of Pharmacy and Health Sciences.

“Over the years, we have learned that consumption of grapes has the potential to mediate an amazing cadre of health benefits. Data suggest health improvements in heart, colon, brain, skin, and more. We now know that grapes can change the chemicals in the microbiome. As these chemicals have access to all of our body organs it is logical to conclude that this leads to some of the health benefits that have now been established.”

Probiota Americas 2023

The event takes place June 14-16, 2023 at the Westin Chicago River North in Chicago. The three-day program will explore the state of the market, postbiotics, how plant breeding can impact the human gut microbiome, the regulatory landscapes for microbiome modulators in the US and Canada, the opportunity with pets, disruptive technologies like CRISPR, A.I., and -omics, microbiome modulation to support women’s health, and LBPs in the USA.

Participants include experts from NOW Health Group, Nouri, Postbiotics+, Microba, the University of Nebraska, the US Food & Drug Administration, Health Canada, Amin Talati Wasserman, the International Probiotics Association, the Broad Institute of MIT and Harvard, North Carolina State University, Synbiotic Health, Zbiotics, Morinaga, Kaneka, IFF, Fonterra, the National Animal Supplement Council, AnimalBiome, Persephone Pharma, ExeGi Pharma, University of São Paulo Medical School, SPINS and more.

Probiota 2023 in Barcelona was sold out, so don’t wait to reserve your spot for the leading annual event for the prebiotic​, probiotic ​and the microbiota ​focused food and pharma industries across the Americas. Register today for Probiota Americas​.       

Source: Scientific Reports
“Influence of grape consumption on the human microbiome”
Authors: A. Dave, et al.


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