More evidence that soy isoflavones boost bone health

By Stephen Daniells

- Last updated on GMT

Related tags: Bone, Osteoporosis

A daily supplement of soy isoflavones reduced bone loss in early
post-menopausal women - says a study from China that has been
welcomed by the company who provided the supplements.

Previous studies have reported conflicting results concerning soy isoflavones (40 to 99 mg/d doses) and bone health for postmenopausal women. But the new study adds to the debate by reporting that high dose soy isoflavone supplements (126 mg/d) did improve bone density, with no severe adverse effects.

Limiting bone loss in post-menopausal women could ease the burden of osteoporosis, a disease that affects half of all women over the age of 50. According to the International Osteoporosis Foundation, the total direct cost of osteoporotic fractures is €31.7 bn in Europe.

Previous studies from China have linked soy isoflavones to increases in bone mineral density (BMD), while a recent large study in the Archives of Internal Medicine​ (2005, Vol. 165, pp. 1890-1895) reported that high soy consumption was linked with a 48 per cent decrease in fractures for women who had been menopausal for less than 10 years.

The researchers, from the Sun Yat-sen University and Acatris Holdings, recruited 90 early-postmenopausal women (average age 52) to take part in the six month single-blind, randomized, placebo-controlled trial.

The women were randomly assigned to one of three groups and received daily soy supplements giving daily isoflavone doses of zero (placebo), 84 milligrams, or 126 milligrams.

The supplements were provided by Acatris (SoyLife) and contained 7.05 per cent isoflavones in the following concentrations: 52 per cent daidzein, 33 per cent glycitein, and 15 per cent genistein.

Bone mineral density (BMD) was measured at the start and end of the trial using dual-energy X-ray absorptiomety (DXA). Urinary excretion of deoxypyridinoline (Dpd) was also measured - Dpd was used as the bone-specific biomarker of bone resorption (bone thinning).

The results, published on-line in the European Journal of Nutrition​ (doi: 10.1007/s00394-006-0602-2), show that at the end of the intervention period, the women taking the highest daily dose had significant benefits on bone loss, particularly ay yje lumbar spine and femoral neck.

Supplementation with 126mg resulted in a 0.36 per cent increase in BMD at the lumbar spine, compared to a 1.42 per cent decrease in the region for the placebo group.

The BMD at the top of the hip bone (femoral neck) increase by 1.57 per cent for the high dose isoflavone group, compared to a 0.59 per cent decrease for the placebo group.

Urinary levels of Dpd increased by 30 per cent in the placebo group, showing that bone thinning was occurring. However, in the high dose isoflavone group there was actually a 3.8 per cent decrease in the Dpd excretion at the end of the intervention period that at the start.

No adverse effects were reported by the volunteers, with the exception of short-lived sensations of thirst at the start of the intervention period.

"Our findings suggested that soy isoflavones had a significantly positive dose-dependent effect on attenuating bone loss at the spine and femur neck possibly via the inhibition of bone resorption in postmenopausal Chinese women,"​ concluded the researchers.

There are several limitations that should be noted with this study. Firstly, the study was single-blind, which may have introduced some observational bias from the researchers, while the sample size and study duration were also relatively small to allow generalization of the results.

The results were welcomed by Acatris, makers of the SoyLife ingredients used in the study, and co-funders of the research.

Jocelyn Mathern, RD and technical specialist, Acatris, said: "It is imperative to find natural, safe and effective alternatives for women to help maintain bone health after menopause - without the risky side effects associated with long-term hormone replacement therapy use.

"This promising research is another step in advancing soy germ isoflavones as a safe, effective option."

Mathern said that more studies were ongoing to investigate the effects of either soy or isoflavones on bone density in humans, including the Osteoporosis Prevention Using Soy (OPUS) study - a multi-site, two-year research study on the use of soy isoflavones to prevent bone loss in 400 postmenopausal women. This study is also using Acatris' SoyLife product, said Mathern.

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