High-dose vitamin D backed for fractures: Meta-analysis

By Nathan Gray contact

- Last updated on GMT

Related tags: Vitamin d supplementation, Osteoporosis, Vitamin d

High-dose vitamin D backed for fractures: Meta-analysis
The use of high-dose vitamin D supplements for the reduction of fractures in the elderly has been backed by a new analysis of clinical trials.

The meta-analysis  – published in the New England Journal of Medicine​ – pooled data from over 31,000 people in 11 randomised clinical trials that looked into the possible benefits of vitamin D supplementation for the reduction of fracture risk.

Led by vitamin D expert, Professor Bischoff-Ferrari from the University of Zurich, Switzerland, the research team found those taking high doses of vitamin D – between 800 and 2,000 International Units (IUs)– sustained 30% fewer hip fractures in addition to 14% less fractures of other bones, when compared to the control groups.

“Our results make a compelling contribution to the existing data on vitamin D and fracture risk in men and women age 65 and older, whose vulnerability to bone density loss and osteoporosis makes leave them prone to fractures resulting from thinning bones,”​ said the vitamin D expert.

Professor Bess Dawson-Hughes, senior author of the study, added: “Taking between 800 and 2,000 IUs of vitamin D per day significantly reduced the risk of most fractures, including hip, wrist and forearm in both men and women.”

“Importantly we saw there was no benefit to taking vitamin D supplements in doses below 800 IUs per day,”​ she added.

Dawson-Hughes added that supplementation with vitamin D is an efficient intervention for a problem that can be costly. She noted that supplements cost pennies whereas the estimated cost of treating a fracture is thousands.

"The average recovery is long and painful and deeply impacts quality of life. After a fracture, older patients may only regain partial mobility, resulting in a loss of independence that is personally demoralizing and that can place added stress on family members and caregivers"

Study details

Bischoff-Ferrari and her colleagues analysed each participant's vitamin D supplementation within and independent of the study protocol, controlling for age, vitamin D blood levels at baseline, additional calcium supplementation and whether the person lived independently or under medical care.

"Evaluation of individual-level data is the gold-standard of meta-analysis,"​ she noted.

The team divided the subjects into quartiles ranging from 0 to 2,000 International Units (IUs) of daily vitamin D intake.

In the top quartile, there was a 30% reduction in hip fracture risk and a 14% reduced risk of fracturing other bones, compared to the control groups.

Dawson-Hughes said the results of the current study would be strengthened by large interventional trials investigating the impact of vitamin D supplementation on fracture risk.

The research team also called for further investigation of the impact of combining calcium supplementation with high doses of vitamin D, as their data was inconclusive.

Source: New England Journal of Medicine
Volume 367, Pages 40-49, doi: 10.1056/NEJMoa1109617
“A Pooled Analysis of Vitamin D Dose Requirements for Fracture Prevention”
Authors: H.A. Bischoff-Ferrari, et al.

Related news

Show more

Related products

show more

An Overview of GRAS, NDI, Novel Food & Master File

An Overview of GRAS, NDI, Novel Food & Master File

Nutrasource Pharmaceutical and Nutraceutical Services | 29-Sep-2022 | Sponsored Link

Join Nutrasource and RNI Consulting as experts discuss key regulatory pathways: GRAS, NDIN, Novel Food and NHP Master File for US, Canada, and EU / UK.

Omega-3 & MenaQ7® K2: A Dynamic Duo

Omega-3 & MenaQ7® K2: A Dynamic Duo

Gnosis by Lesaffre USA | 15-Sep-2022 | Infographic

Omega-3 and Vitamin K2 as MK-7 have compelling health claims with validated mechanisms of action for the heart. But by balancing Calcium metabolism, K2...

Improve DOMS and Postexercise Lactate Accumulation

Improve DOMS and Postexercise Lactate Accumulation

Gencor-Pacific | 08-Sep-2022 | Clinical Study

Hydrocurc®’s clinical study suggests that a highly bioavailable curcumin may facilitate a quicker return to exercise training and/or allow a higher training...

Related suppliers

1 comment

Vitamin D better than bone drugs

Posted by Jacqueline,

Not only does this not surprise me, but there are other studies that show vitamin D is better than bone drugs at preventing fracture.

Report abuse

Follow us

Products

View more

Webinars