High-dose vitamins and minerals offer no benefit for recurrent 'cardiac events'

High-dose vitamins, minerals no benefit for recurrent cardiac events
Supplementation with vitamins and minerals does not help to reduce recurrences of cardiac events in people who have suffered a heart attack, says research.

The new study data, which is as yet unpublished but was presented at the American College of Cardiology's 62nd Annual Scientific Session, suggests that heart attack patients who are given a combination of high-dose oral vitamins and minerals do not show significant reductions in recurrent cardiac events.

The results comes from the NIH-funded Trial to Assess Chelation Therapy (TACT) study, for which previous results have shown that when combined with active chelation therapy, such high-dose supplements can offer additional benefits.

"We did not see a significant benefit of vitamins alone for patients who had a heart attack​," said lead author of the study Dr Gervasio Lamas, from Columbia University Mount Sinai Medical Center.

"Interestingly, patients who received both high dose vitamins and active chelation compared to placebo of both appeared to have additional benefit,"​ he said, noting that more research is required to understand why vitamin and mineral supplements offer no benefit on their own but do offer additional benefits when coupled with chelation.

Study details

The TACT study tested the safety and effectiveness of both EDTA chelation therapy and high-dose vitamin and mineral supplements in a group of 1,708 individuals with prior heart attacks.

The participants were split to receive one of four patterns of treatment: active chelation plus active oral vitamins, active chelation plus placebo oral vitamins, placebo chelation plus active oral vitamins, or placebo chelation plus placebo oral vitamins.

Since 1956, alternative medicine practitioners have used EDTA chelation to treat cardiovascular disease.

Chelation therapy involves multiple intravenous infusions of a synthetic amino acid called EDTA, which binds to certain minerals and metals, including calcium, lead and cadmium. The practice has been used as a way to treat cardiovascular disease by some alternative therapists.

Lamas and his colleagues, said that this 2 x 2 factorial design allowed them to clarify the independent contributions of each treatment.

Over the four years of follow-up, the active/active arm had 108 (26%) events and the placebo/placebo arm had 139 (32%) events—a statistically significant difference.

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And actually, as Dr. Rodanoff notes, it's missing important nutrients

Posted by Michael Mooney,

It's missing minerals, such as magnesium, which more and more we see is crucial for optimum cardiovascular function, not to mention the other essential minerals.
So this formula is highly deficient, if we consider all the nutrients that are essential for complete metabolic function.

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Study Nutrient Doses

Posted by Michael Mooney,

You can view the "high dose" nutrient formula as Table IV at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243954/
Vitamin A - 25,000 IU
C - 1,2000 mg - barely enough to do much
D3 - 100 IU -- far too low to do anything
E 400 IU - the lowest effective potency for reducing LDL oxidation (Fuller, Am J Cardiol 1998 Jan 15;81(2):232-3.)
K1 - 60 mcg - is that enough?
B1 - 100 mg
Niacin - 200 mg - not a therapeutic dose
B6 - 50 mg - on the low side of full effectiveness
Folate - 800 mcg
B12 - 100 mcg
Biotin - 300 mcg
This formula could provide a small improvement, as seen, but, except for vitamin A it's not a truly strong high potency formula.

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What nutrients were in the supplement?

Posted by A. Rosanoff, Ph.D.,

Was there magnesium above 150 mg/day in the vitamin-mineral supplement given to these patients? If not, then perhaps the chelation therapy removed some of the Ca, making for a more healthy Ca:Mg ratio and thus the small change in cardiovascular events. We need to know what vitamins/minerals are given and in what amounts to truly assess this study.

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