Pickle-derived probiotic linked to longer lifespan, for worms at least

By Stephen Daniells contact

- Last updated on GMT

The study assessed the potential of a bacterium isolated from pickles to extend lifespan in nematodes.   Image © bigacis / Getty Images
The study assessed the potential of a bacterium isolated from pickles to extend lifespan in nematodes. Image © bigacis / Getty Images

Related tags: Probiotics, longevity, lifespan, anti-aging, Pediococcus

A specific bacterium isolated from fermented pickles may extend lifespan in nematode worms, says a new study from China that may “provide the theoretical basis for its future application”.

Caenorhabditis elegans​ or C. elegans​ is often used in studies related to aging because the worms are transparent, making cellular activity easier to view, and they have a short lifespan. But most importantly, they are a simple organism with specific types of metabolic genes that are similar to mammals.

A review in the International Journal of Molecular Sciences​ in 2019  noted that several studies have reported that select probiotics may “exert anti-ageing effects in nematodes by acting on common molecular pathways, such as insulin/insulin-like growth factor-1 (IIS) and p38 mitogen-activated protein kinase (p38 MAPK).

“In this perspective, C. elegans appears to be advantageous for shedding light on key mechanisms involved in host pro-longevity in response to probiotics supplementation.”

New data published in Frontiers in Nutrition​ indicated that the fermented pickles-origin Pediococcus acidilactici​ may again exert lifespan-extending benefits via the promotion of insulin/IGF-1 signaling and JNK/MAPK signaling.

In addition, scientists from University of Science and Technology Beijing (USTB) and the Beijing Beike Institute of Precision Medicine and Health Technology reported that P.acidilactici​ may also reduce fat accumulation in the worms.

The study also found that the probiotic also impacted chloride ion-associated genes linked to inflammation in the nematodes, which may impact lifespan.

“Therefore, it is speculated that the ​[P. acidilactici] might play an important role in the anti-aging activities via the modulation of chloride ion-related genes, providing a new perspective to explore the lifespan extending effect,” ​wrote the researchers.

“Besides, the study has a vital referential significance for other probiotics screening and provides the theoretical basis for its future application.”

Mining centenarians for beneficial bugs?

As reported by NutraIngredients-USA in 2021​, Chinese scientists reported that four probiotic strains isolated from Centenarians may exhibit anti-aging potential and protect against neuro-inflammation via the microbiota-gut-brain axis.

That data, which was derived from a study with lab mice and published in Frontiers in Immunology,​ indicated that the combination of Limosilactobacillus fermentum​ SX-0718, Lacticaseibacillus casei​ SX-1107, Bifidobacterium longum​ SX-1326, and B. animalis​ SX-0582 also upregulated the expression of Sirt 1 to protect neurons in the hippocampal region of the brain.

Additionally, the probiotic combination, which was isolated from the feces of seven centenarians of the Centenarian Village in Ganzhou, Jiangxi province, China, was associated with an increase in the expression of molecules that improve the integrity of the intestinal barrier and reduce leaky gut.

Source: Frontiers in Nutrition
Published online, doi: 10.3389/fnut.2022.821685
“Pediococcus acidilactici Promotes the Longevity of C. elegans by Regulating the Insulin/IGF-1 and JNK/MAPK Signaling, Fat Accumulation and Chloride Ion”
Authors: R. Hu et al.

 

 

 

 

                                                                                                                                                                                             

Related news

Related products

show more

Set your brand apart with Collavant n2

Set your brand apart with Collavant n2

BIOIBERICA, S.A.U. | 17-May-2022 | Technical / White Paper

Native type II. Hydrolysed. Undenatured. There’s a variety of collagen products available on the market – but how can formulators identify the solution...

Health, Wellness and Innovation made easy

Health, Wellness and Innovation made easy

Univar Solutions | 16-May-2022 | Product Brochure

Tata Fossence®, a short chain FOS, is a potent prebiotic and dietary fibre derived from fermented cane sugar that selectively enhances the beneficial microbiota...

MEDITERRANEAN INGREDIENTS FOR HEALTH AND WELLNESS

MEDITERRANEAN INGREDIENTS FOR HEALTH AND WELLNESS

BIONAP BIOACTIVE NATURAL PRODUCTS | 29-Apr-2022 | Product Catalog

BIONAP is positioned to lead the next generation of natural and organic ingredients with the aim to improve health and quality of life over the world.

Clinically supported probiotics and postbiotics.

Clinically supported probiotics and postbiotics.

ADM | 26-Apr-2022 | Product Presentation

Today’s consumers know the importance of metabolic health and the role that the gut microbiome plays within it. After extensive research, ADM has selected...

Related suppliers

Follow us

Products

View more

Webinars