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support for brain health and memory

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Clinically-validated, natural support for learning and memory through all life stages

Modern life demands sustained focus, adaptability and mental resilience.

Cognitive fatigue, information overload and stress exposure have become part of daily routines for both adults and students. As global awareness of brain health grows, scientific attention is shifting toward naturally derived compounds that help maintain neural performance without overstimulation or dependency.

Modern living environments – characterized by continuous information flow, high productivity expectations and persistent psychological stress – have increased the need for safe, sustainable cognitive support. In parallel, consumers increasingly prefer natural compounds perceived as gentler on the nervous system and suitable for long-term use.

This broader market trend has encouraged researchers to explore naturally derived peptides, botanicals and nutrient-based interventions that may support cognitive performance through mechanisms distinct from conventional stimulants.

Developed over 30 years of neuroscience research in Korea, Brain Factor-7® (BF-7) is a silk-fibroin-derived peptide complex, naturally sourced, studied extensively by Famenity Co., Ltd. Its cognitive applications have been explored through a wide range of human and preclinical studies, building a strong foundation of scientific evidence and safety data.

From science to innovation

BF-7® is a proprietary low-molecular-weight peptide complex produced through Famenity’s specialized fibroin-processing technology. This unique approach isolates specific neuroactive peptide fractions – not obtainable from general silk or fibroin extracts – that are capable of interacting with neuronal membranes and supporting synaptic communication.

The discovery emerged from neurobiology research examining fibroin-derived peptides under oxidative and metabolic stress. Early laboratory findings showed meaningful protection against neuronal damage and improved functional signaling, forming the basis for the extensive clinical research that followed.

Neural Network Pathways

Clinically demonstrated benefits across the lifespan

Over 12 human clinical studies conducted with leading university hospitals and research institutes in Korea consistently demonstrated BF-7®’s capacity to improve attention, learning ability, memory, reasoning, and overall cognitive function across all life stages.1-8;12

Children: Enhancing attention and learning ability

A placebo-controlled clinical trial in elementary school children aged 7 to 12 reported that eight weeks of BF-7® supplementation significantly enhanced concentration, responsiveness and classroom engagement.7

Teachers and parents observed improved attentiveness and academic performance, reflecting better information processing and classroom behavior. Overall, BF-7® promoted learning readiness and attention control in developing brains.

Brain Network Activation

Elementary students: Strengthening memory and reasoning skills

In another study of children aged 7 to 12, regular intake of BF-7® improved overall learning ability and memory quotient (MQ), showing better comprehension, reasoning and recall performance.8 These findings suggest BF-7® helps strengthen both short- and long-term memory processes, contributing to intellectual flexibility and confidence in study activities.

Middle and high school students: Supporting academic performance

Adolescents under high academic pressure showed measurable improvements in concentration, learning efficiency and logical reasoning following BF-7® administration.2 The supplementation group exhibited higher learning motivation and reduced mental fatigue, confirming BF-7®’s role in supporting mental endurance during prolonged cognitive effort.

University students and young adults: Reinforcing learning, logic and mental efficiency

A randomized, double-blind, placebo-controlled clinical trial in university students and young adults aged 19 to 29 demonstrated that four weeks of BF-7® supplementation significantly improved memory quotient (MQ), learning capacity and reasoning accuracy.12 EEG (P300) analysis confirmed faster cognitive processing, reduced neural tension and greater mental efficiency. These results show that BF-7® enhances higher-order cognitive function and neural adaptability in young adults.

Adults: Enhancing working memory, decision-making and concentration

In controlled studies with healthy adults, BF-7® supplementation improved overall MQ scores by approximately 20%, with measurable gains in learning comprehension, reasoning and sustained attention.1-2;4-6 Participants reported clearer thinking and faster decision-making. Studies using BF-7®-fortified milk further demonstrated improvement in attention, mathematical reasoning and problem-solving ability, reinforcing its practical value for daily mental performance.5-6

Older adults: Supporting cognitive vitality and recall ability

In elderly participants, continuous BF-7® intake led to measurable improvements in global cognition, recall accuracy and memory stability, alongside better subjective focus and reduced forgetfulness.1-3 Participants also reported improved emotional stability and mental wellbeing. These findings suggest BF-7® supports cognitive vitality and healthy brain aging by improving neuronal communication and efficiency.

EEG (P300) results in enhanced processing efficiency were demonstrated in young adults, while children’s outcomes were evaluated through behavioral and cognitive indices.7-8;12

Independent clinical studies across all ages

Objective physiological and neurofunctional evidence

The cognitive benefits of BF-7® are supported by multimodal physiological and neurological findings:

  • EEG (P300) Improved attention accuracy and faster information processing in young adults.12
  • Behavioral metrics Significant improvements in learning and MQ observed across multiple age groups.7-8;12
  • Preclinical findings Demonstrated antioxidant and neuroprotective effects, including reduced oxidative stress and ischemic damage.9-11;13

These results confirm BF-7®’s ability to enhance both cognitive performance and underlying neuronal health.

Mechanism of action

  1. Synaptogenesis and neuronal network enhancement BF-7® promotes synaptic formation and strengthens neuronal connectivity, improving learning and information transfer efficiency.1-2
  2. Mitochondrial activation It enhances neuronal adenosine triphosphate (ATP) production and energy metabolism, supporting sustained cognitive function under stress or fatigue.3,13
  3. Neurotransmitter modulation BF-7® supports acetylcholine synthesis and signaling, essential for focus, learning and memory.1,4
  4. Neuroprotection under ischemic and oxidative stress BF-7® reduces oxidative stress and neuronal apoptosis, showing protective effects in ischemic and neurodegeneration models.9-11;13
The paradigm shift: Genuine BF-7

Regulatory recognition and safety

  • Korean Ministry of Food and Drug Safety (MFDS) Individually certificated for memory improvement (Functional Ingredient No. 2009-46).
  • US Food and Drug Administration (FDA) Acknowledged as a NDI.
  • Health Canada Licensed under Natural Product Number (NPN).
  • Halal Certified Meeting international food and safety standards.

With over 20 years of commercialization and no reported adverse events, BF-7® demonstrates outstanding safety.1-13 Manufacturing adheres to Good Manufacturing Practice (GMP), International Organization for Standardization (ISO), and Food Safety System Certification (FSSC) standards to ensure consistent quality and peptide bioactivity across formats such as tablets, powders, gummies and beverages.

National recognition and global reach

BF-7® was selected by the Korean Ministry of Science and ICT as one of the nation’s Top 100 National R&D Achievements, highlighting its contribution to cognitive health innovation.13 It is also the official brain health sponsor of the Korea National Shooting Team, representing precision, focus and mental resilience.

Today, BF-7® is commercialized in over a dozen countries, including the US, Germany, Brazil, Australia and New Zealand, as a premium ingredient for brain and performance nutrition.

The verified global standard

All published research validating BF-7®’s efficacy was conducted using Famenity’s genuine fibroin peptide, produced through Famenity’s exclusive proprietary process that defines its unique peptide composition and biological activity.1-13 Genuine BF-7® is protected by patents and trademarks across the US, Canada, Europe, Japan and Australia, ensuring authenticity and scientific reliability for all products bearing the BF-7® name.

References

  1. Kim S.Y.; et al. The Role of BF-7® on Neuroprotection and Enhancement of Cognitive Function. Korean J. Physiol. Pharmacol. 2004; 8(4): 173-180.
  2. Kim H.S.; et al. The Improvement of Learning and Memory Ability of Normal Persons by BF-7®. Korean J. Physiol. Pharmacol. 2004; 8(6): 307-312.
  3. Park J.H.; et al. Association between Cerebral Blood Flow and Cognitive Improvement Effect by Bombyx mori Extracted Component. Korean J. Sericultural Sci. 2004; 46(2).
  4. Kim Y.J.; et al. Neuroprotective Effects and Physicochemical Characteristics of Milk Fortified with Fibroin BF-7®. Korean J. Food Sci. Anim. Resour. 2008; 28(4):431-436.
  5. Kim D.H; et al. Milk with Brain Factor-7® (BF-7® Milk) Enhances Attention and Cognition in Normal Persons. Milchwissenschaft. 2009; 64(3): 300-304.
  6. Kim J.S.; et al. Milk Containing BF-7® Enhances Learning, Memory, Attention, and Mathematical Ability of Normal Persons. Korean J. Food Sci. Anim. Resour. 2009; 29(2):278-282.
  7. Lee J.H.; et al. Brain Factor-7® Extracted from Bombyx mori Enhances Cognition and Attention in Normal Children. J. Med. Food. 2009; 12(3):643-8.
  8. Park J.H.; et al. The Improvement of Short- and Long-term Memory of Young Children by BF-7®. J. Korean Soc. Food Sci. Nutr. 2010; 39(3):376-382.
  9. Kwon O.B.; et al. Amine-Modified Single-Walled Carbon Nanotubes Protect Neurons from Injury in a Rat Stroke Model. Nature Nanotechnology. 2011; 6(2):121-125.
  10. Choi Y.K.; et al. Neuroprotective Effects of Brain Factor-7® Against Motor Deficit and Oxidative Stress in a Mouse Model of MPTP-Induced Parkinson’s Disease. Exp. Ther. Med. 2022; 24;24(4):635.
  11. Lee H.S.; et al. Brain Factor-7® Improves Cognitive Impairment Following Transient Ischemia and Reperfusion Injury in Gerbil Forebrain. Front. Biosci. (Landmark Ed.). 2022; 27(12):337.
  12. Kim B.R.; et al. The Improvement of Attention, Long-Term and Short-Term Memory by Brain Factor-7® (BF-7™). Food Supplement and Biomaterials for Health. 2022; 2(1):e1.
  13. Kim D.H.; et al. Brain Factor-7® Improves Learning and Memory Deficits and Attenuates Ischemic Brain Damage by Reducing ROS Generation in Stroke In Vivo and In Vitro. Lab Anim. Res. 2020;36:24.