Obesity and overweight are considered to be major risk factors for a number of metabolic diseases such as diabetes, hypertension and cardiovascular diseases, leading to reduced life expectancy. Therapeutic weight loss includes a combination of diet, exercise and behaviour modification, but natural active substances offer a safe and effective support to the management of body weight. MOROSIL® is a solid ingredient obtained from the juice of Moro oranges (Citrus sinensis (L.) Osbeck), clinically proven to reduce weight gain and fat accumulation and to prevent human obesity.