Dietary histamine is an often-overlooked contributor to meal-related digestive discomfort and allergy-like reactions.
This white paper explores endogenous vs. exogenous histamine, food categories linked to higher exposure, and common reaction patterns associated with histamine intolerance.
It reviews human clinical evidence on oral diamine oxidase supplementation and outlines key formulation considerations for supplement developers.
For brands innovating in this space, adiDAO® and adiDAO® Veg offer rigorously standardised DAO ingredients for activity-based dosing.



