Hormone treatment for rare diabetes disorder

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Related tags: Leptin, Diabetes mellitus, Obesity, Diabetes

Researchers in the US have successfully used the hormone leptin to
treat patients suffering from lipodystrophy, a rare and
difficult-to-treat disorder that shares some of thecharacteristics
of typical type 2 diabetes.

Researchers in the US have successfully used the hormone leptin to treat patients suffering from lipodystrophy, a rare and difficult-to-treat disorder that shares some of thecharacteristics of typical type 2 diabetes.

The findings by scientists at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the University of Texas Southwestern Medical Center appear in the 21 February issue of the New England Journal of Medicine.

"This is the first example of leptin's use in a therapeutic role in a rare form of diabetes,"​ said Dr Phillip Gorden of the NIDDK, the study's senior investigator.

People with lipodystrophy have few or no fat cells and thus lack leptin, a hormone produced by and stored in fat cells. As a result, people with the condition usually store huge amounts of lipids in inappropriate places like muscle or liver, and have extremely high levels of lipids in their blood. These patients are likely to be insulin resistant, meaning their bodies do not readily respond to insulin, the hormone that allows muscle and fat cells to properly use glucose.

Eight of the nine female patients who participated in the study had diabetes and were taking either insulin or a diabetes drug, or a combination of the two. During the four-month study, most patients experienced significant improvements in levels of fasting glucose, haemoglobin A1c (A1c), which measures a person's average blood glucose over the three previous months, and triglycerides (a kind of lipid).

Patients were able to reduce or stop using insulin and drugs to control their diabetes, and they reported eating less following treatment. The findings suggest that leptin reduces insulin resistance and prevents the body from accumulating fat in the wrong places.

"It is too soon to make the assumption that leptin will be useful in typical type 2 diabetes,"​ said Gorden. Although people with lipodystrophy and type 2 diabetes can develop some of the same complications when blood glucose is uncontrolled, the two conditions differ in fundamental ways. Most people with typical type 2 diabetes are overweight and not deficient in leptin. In fact, their leptin levels are usually high, and they may be resistant to leptin's effects, Gorden stressed.

The rationale for treating lipodystrophy with leptin comes from classical endocrinology. "The idea is that if people have a hormone deficiency and they are given a replacement hormone, they should respond,'​ said Gorden.

"What we have shown is that in a leptin-deficient state, we can correct many of the abnormalities that come with it,"​ added Dr Elif Arioglu Oral, the paper's lead author and a former research fellow at NIDDK.

The results also suggest that leptin deficiency may explain the insulin resistance seen in people with lipodystrophy. "For the first time, we're seeing leptin working as an insulin-sensitising agent,"​ Oral said. Earlier leptin studies showed that lack of the hormone caused obesity in mice; resistance to leptin also contributed to obesity in mice and humans.

In the eight diabetic patients in the study, the decreasein haemoglobin A1c was 1.9 percentage points. Healthy people with no diabetes have an A1c lower than six; the goal for people with diabetes is lower than seven. At the beginning of the study, only two patients had an A1c lower than eight; by the end of the study, eight patients had A1c levels lower than eight.

For all patients, average fasting triglyceride levelsdropped by approximately 60 per cent and liver volume dropped by 28 per cent. The normal range for plasma triglycerides is 35 to 155 mg/dL. The level for patients at the start of the study ranged from 445 to 9,560. At the study's conclusion, the range was 123 to 1,214.

The change in the patient with the highest triglyceridelevel was dramatic, said Oral. The patient had failed to respond to any medication, the extra lipid had deposited in the skin, causing a lot of pain, and her liver was very enlarged. To remove the triglycerides, every week she had to go through pheresis, a process where blood is removed, components are separated out, and the blood is returned to the body. Within three months of leptin therapy her liver had shrunk and she was off pheresis, Oral said.

To better understand how much leptin people really need, the NIDDK has begun studying people with less severe lipodystrophy. "There is probably a critical level fornormal insulin sensitivity," said Oral.

Related topics: Research

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