€6m EU project seeks satiety answers to EFSA’s health claim riddles

By Shane Starling

- Last updated on GMT

“We have anticipated EFSA requirements.." says SATIN leader, Dr Jason Halford.
“We have anticipated EFSA requirements.." says SATIN leader, Dr Jason Halford.

Related tags Nutrition

Coca-Cola, Cargill, Naturex, NIZO and others are partnering with academia in a satiety project that is building science with an eye firmly planted on winning weight management health claims under new EU laws.

The SATIN project, as it is known, even has two members from a sub-committee of the European Food Safety Authority’s (EFSA) health claims panel onboard to advise it.

The project is being led by the University of Liverpool ‘s Professor Jason  Halford, PhD, who told NutraIngredients SATIN was the first project of its kind to be both science and end-product focused.

It is for this reason the commercial partners have added €2m to the €6m EU funding.

“Intelligent combinations of ingredients”

“That is why we are focusing on satiety diets rather than particular ingredients,”​ Dr Halford, from the Human Ingestive Behaviour laboratory at Liverpool University, said. “We are looking at intelligent combinations of ingredients.”

“We have anticipated EFSA requirements and are building those into the studies we are constructing. In a way this is beautifully timed coming as it does as EFSA has just published guidelines about weight management health claim submissions.”

Ingredients that are being examined include, “the typical suspects”​ like proteins, fibres, protease inhibitors and novel lipids.

“We are using food chemistry to alter food structure to deliver the right ingredients to the right place – the gastrointestinal tract – at the right time.”

 The project runs in two phases:

  • Phase 1. Establish new metrics for performance measurement. Will run until 2015.
  • Phase 2. Take ingredient combinations into gold standard trials. 2015-2016.

Educating EFSA

Dr Halford said the project had a supplementary goal to, “educate EFSA about satiety science”​ as the EFSA guidance​ had been clearer about weight loss than the idea of satiety.

Initially SATIN will focus on in vitro​ modelling, which will be used to inform human clinical trials. Animal models will not feature due to their lack of importance with EFSA.

 Halford added in a statement: “Obese and overweight people are  less likely to feel full after eating, partly because of the energy-dense foods they prefer have a reduced  impact on gastrointestinal hormone signals that help promote feelings of satisfaction and fullness.” 

“SATIN aims to draw upon our improved understanding of appetite expression - how the foods we eat affect eating behaviour and appetite. If we can produce foods that fill people up quicker and for longer  and taste good then we can help moderate appetite whilst maintaining a healthy balanced diet.”

Advisory board partners are the Beneo Group, Kraft Foods, Kellogg’s, Kemin Health, Fonterra, GlaxoSmithKline and Sensus.

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SATIN and EFSA - http://www.satin-satiety.eu/

Posted by Jason Halford SATIN co-ordinator,

We thank the Nutraingredients.com team for highlighting the SATIN. The SATN project ( http://www.satin-satiety.eu/ ) is a five year project with considerable industry involvement. It has two phases - Phase one will 1) develop new foods using key ingredients and novel food structures and 2) validate in vitro (non-human) screenings processes to speed up product development. Phase two will 1) put individual novel foods through gold standard clinical trials to both fulfil and inform EFSA criteria for appetite control and weight management, and then 2) test the entire satiety approach to consumer weight control using multiple foods in a large scale multi site long term weigh management trial.

The SATIN consortium does not seek to educate EFSA per se about satiety. Some of SATIN's members worked with EFSA at the inception of appetite health claims substantiation, others have contributed to the EFSA review process, and many also provided EFSA formal feedback on the Draft guidance. However, the outcomes of SATIN will inform the ongoing EFSA health claims processes. We look forward to sharing our findings with you and there will be more details of SATIN at VITAFOODs in May where we will be speaking again with Shane and the Nutraingredients team

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SATIN and EFSA - http://www.satin-satiety.eu/

Posted by Professor Jason C G Halford SATIN - Co-ordinator,

Thanks to Shane and the Nutraingredients team for this important coverage of the SATIN project.

SATIN (http://www.satin-satiety.eu/ ) is a five year two phase collaborative project with considerable industry invovlvement.

Phase one 1) develops new foods using key ingredients and novel food structures and 2) validates new in vitro (non-human)screening approaches.

Phase two 1) puts each ingredient through gold standard clinical trials to both fulfil and inform EFSA criteria(for appetite control and weight management) and then 2) tests the entire satiety approach using multiple foods in a large scale multi site long term weight management.

SATIN does not aim to 'teach' EFSA about Satiety as some of the consortium members have already worked closely with EFSA from the inception of appetite health claims, others have worked with EFSA in the claims review process and many have also formally responded to the draft guidence.

However, the SATIN programme of work will generate outcomes that will further inform the EFSA health claims process.

SATIN looks forward to sharing the results of this exciting project with you all. We will be at VITAFOODs and speaking to Shane and the team there further.

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