Vitamin D supplements may not offer osteoarthritis benefits: Study

By Nathan Gray contact

- Last updated on GMT

Vitamin D supplements may not offer osteoarthritis benefits: Study

Related tags: Vitamin d

Supplementation with vitamin D does not reduce key symptoms of osteoarthritis including cartilage loss and joint pain, according to the findings of a two year clinical trial.

The randomised clinical study – published in JAMA​ – investigated whether vitamin D supplementation was effective at reducing the symptoms and structural progression of knee osteoarthritis.

Led by Professor Timothy McAlindon from Tufts Medical Center, USA, the trial findings reveal that patients with symptomatic knee osteoarthritis who received vitamin D supplementation did not have a significant difference in primary outcome measures including knee pain and cartilage volume loss when compared to patients who received placebo.

“Vitamin D supplementation for 2 years at a dose sufficient to elevate 25-hydroxyvitamin D plasma levels to higher than 36 ng/mL, when compared with placebo, did not reduce knee pain or cartilage volume loss in patients with symptomatic knee OA,”​ wrote McAlindon and his colleageus.

“In summary, the results of this trial together with recent observational data indicate that vitamin D does not have a major effect on knee OA symptoms or progression among individuals who have a 25-hydroxyvitamin D level higher than 15 ng/mL,”​ they added.

Study details

The two-year randomised, placebo-controlled clinical trial included 146 participants with symptomatic knee OA. All participants were randomised to receive either placebo or oral cholecalciferol (2,000 IU/day) with dose escalation to increase serum levels to more than 36 ng/mL, the research team explained.

The primary measured outcomes for the study were knee pain severity (Western Ontario and McMaster Universities [WOMAC] pain scale), and cartilage volume loss measured by magnetic resonance imaging. Secondary outcomes included physical function, knee function (WOMAC function scale), cartilage thickness, bone marrow lesions, and radiographic joint space width.

“Knee pain fell by about 2 units in both groups,”​ said the team, who noted that the effect of treatment over time was not significant.

They added that cartilage volume decreased by around 4% in both the vitamin D and placebo groups.

Source: JAMA
Volume 309, Number 2, Pages 155-162, doi: 10.1001/jama.2012.164487​ 
"Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis. A Randomized Controlled Trial"
Authors: Timothy McAlindon, DMichael LaValley, Erica Schneider, Melynn Nuite, et al

Related news

Show more

Related products

show more

Going Organic: a new chapter in supplements

Going Organic: a new chapter in supplements

INNOBIO Corporation Limited | 21-Sep-2020 | Data Sheet

"Organic" is more of a healthy lifestyle. Rising consumer awareness of organic products and widening availability are two major drivers of global...

Vit K2 Deficiency: Impeding Optimal Health For All

Vit K2 Deficiency: Impeding Optimal Health For All

NattoPharma USA, Inc. | 10-Aug-2020 | Technical / White Paper

NattoPharma created the Vitamin K2 category, driving all research demonstrating bone- and heart-health benefits of MenaQ7® Vitamin K2 as MK-7. That research...

Related suppliers

1 comment

knee ache

Posted by arthritis,

I am a big fan of your blog. i am so excited by read of your blog's content. really great post.Thanks for sharing superb informations. Your web-site is very cool. I am impressed by the details that you have on this blog.

Report abuse



Follow us


View more