High dose B vitamins help prevent Alzheimer’s, says researchers

By Oliver Nieburg contact

- Last updated on GMT

Brain deterioration less pronounced in people taking B Vitamins
Brain deterioration less pronounced in people taking B Vitamins
A new study is suggesting that a high dose of B vitamins could stop the onset of Alzheimer’s by preventing shrinkage of the medial temporal lobe, the area of the brain that defines the disease.

The research by Douaud et al.​ published in the Proceedings of the National Academy of Sciences ​found that this part of the brain shrank slower in people with mild cognitive impairment when they took B Vitamins.

To reach these conclusions, the researcher gave 156 elderly people with mild cognitive impairment, the stage before dementia or Alzheimer’s, a combination of vitamin B12 (500 mcg), B6 (20 mg) and folic acid or placebo pills over a two year period.

The 80 subjects receiving B Vitamins showed significantly less brain degeneration than the placebo group.

Disease shrinks eight times

Lead researcher David Smith of Oxford University said: "In those with high homocysteine levels, the specific areas of the brain associated with Alzheimer's, disease shrank eight times more slowly in those taking B vitamins than in those on the placebo.”

“This is strongly indicative that the B vitamins may be substantially slowing down, or even potentially arresting, the disease process in those with early stage cognitive decline.”

“This is the first treatment that has been shown to potentially arrest Alzheimer’s related brain shrinkage.”

Research Author: Elderly could benefit

Previous research has shown that raised levels of plasma total homocysteine (tHcy) are associated with cognitive impairment, Alzheimer's Disease, or vascular dementia.

The present study concluded that B-vitamin treatment could lower mean plasma tHcy levels by 29%.

Smith said: "This makes the need for early screening for the first signs of cognitive decline from the age of 50…vitally important, backed up by homocysteine testing and potential B vitamin treatment.

“Our study shows that those with a homocysteine level above 10mcmol/l, which is about half of all people over age 65, potentially may benefit with reduced brain shrinkage by taking high dose B6, B12 and folic acid, but this should be done under medical supervision.”

Source:
Proceedings of the National Academy Sciences ​(In Press)
‘Preventing Alzheimer's disease-related gray matter atrophy by B vitamin treatment’
Authors: Douaud, G., et al.

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3 comments

High Dose B-Vitamins?

Posted by Larry,

So the medical establishment now thinks that 1 mg of B-complex vitamins are not enough? Welcome to the 20th century. Unfortunately, having to drag medical professional and scientists kicking and screaming to the understanding that the human body show deficiency diseases in different ways. So what is next? Vitamin C can prevent cancer?

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Interaction of micronutrients in albumin glycation

Posted by Dr. Vaishali Agte,

This article interests us since we had extensively studied in vitro effects of micronutrients i.e. both vitamins and trace metals in protein glycation, an event playing major role in development of AD. I am giving below our published work.
1. Kirtan V. Tarwadi and Vaishali V. Agte Effect of micronutrients on methylglyoxal mediated in vitro glycation of albumin Biol Trace Elem Res. Volume 143, Issue 2 (2011), Page 717-725.
2. Rashmi Tupe and Agte Vaishali*, Interaction of zinc, ascorbic acid, and folic acid in glycation with albumin as protein model. . Biol Trace Elem Res. 2010 Dec;138(1-3):346-57.
3. Rashmi Tupe and Agte Vaishali Role of zinc along with ascorbic acid and folic acid during long-term in vitro albumin glycation.British J. Nutr. 2009, 103, 370–377.

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Excellent!

Posted by Manta Maunola,

Very good news!

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