Low vitamin D status linked to cognitive decline: Rat study

By Nathan Gray contact

- Last updated on GMT

Low vitamin D status linked to cognitive decline: Rat study

Related tags: Old age, Middle age

Dietary deficiencies in vitamin D may promote cognitive declines in middle-aged and elderly adults, according to new research.

The study, published in Free Radical Biology and Medicine​, manipulated serum vitamin D status in rats using dietary supplementation with low, moderate/control, or high levels of the vitamin from middle to old age in order to assess changes in vitamin D-dependent proteome expression in the brains of the rats.

Led by Professor Allan Butterfield from the University of Kentucky, the research team found that middle-aged rats fed a diet low in vitamin D (VitD) for several months developed free radical damage to the brain and a significant decrease in cognitive performance on tests of learning and memory - with redox proteomics showing that many different brain proteins were damaged.

"Given that vitamin D deficiency is especially widespread among the elderly, we investigated how during aging from middle-age to old-age how low vitamin D affected the oxidative status of the brain,"​ explained Butterfield.

"This study is the first to demonstrate that a chronic low-VitD diet and consequential low levels of VitD in the bloodstream result in significant increases in tyrosine nitration in brain proteins, alterations in glucose metabolism, and mitochondrial changes in brain of elderly rats,"​ said the team.

Related news

Show more

Related products

show more

Adulteration: Don’t Be Fooled, Know the Facts

Adulteration: Don’t Be Fooled, Know the Facts

Sabinsa: our innovation is your answer® | 09-Jul-2018 | Technical / White Paper

Increased knowledge and awareness of natural products has in turn increased their global demand. This well documented paper highlights various examples,...

The full spectrum of natural Vitamin E isomers

The full spectrum of natural Vitamin E isomers

BGG Europe SA | 02-Jul-2018 | Technical / White Paper

BGG Rice tocotrienols/tocopherols mixtures - the full spectrum of tocotrienols and tocopherols extracted from rice bran: Health benefits and labeling information...

Learn how Neumentix™ works for active consumers

Learn how Neumentix™ works for active consumers

Kemin Human Nutrition & Health | 22-May-2018 | Technical / White Paper

New clinical trial data revealed Neumentix improved young recreationally active participants’ cognitive and physical performance after 30 days of supplementation...

Related suppliers

Follow us

Featured Events

View more

Products

View more

Webinars