Science short

Study: Vitamin A form shows breast cancer prevention potential

By Shane Starling

- Last updated on GMT

"It looks like retinoic acid exerts effects on cancer cells in part via the modulation of the epigenome."
"It looks like retinoic acid exerts effects on cancer cells in part via the modulation of the epigenome."

Related tags: Breast cancer, Cancer

A vitamin A form called retinoic acid that is commonly found in sweet potatoes and carrots, can help turn breast cells showing cancerous potential back to a healthy state, researchers have found.

Writing in the International Journal of Oncology, ​Sandra V Fernandez, PhD, assistant research professor of Medical Oncology at Thomas Jefferson University,​ said vitamin A had not been shown to help those with breast cancer, but in a pre-state, could deliver benefits at particular doses.

"It looks like retinoic acid exerts effects on cancer cells in part via the modulation of the epigenome,"​ she said.

"We were able to see this effect of retinoic acid because we were looking at four distinct stages of breast cancer. It will be interesting to see if these results can be applied to patients."

The in vitro​ study focused on four types of cells: Normal; pre-cancerous; cancerous; fully aggressive.

After retinoic acid was introduced the pre-cancerous cells looked more normal and their genetic signature reverted to a healthy one, with 443 genes reverting to a healthy state.

Fully cancerous cells did not respond to the retinoic acid.

The research was funded by Friends for an Earlier Breast Cancer Test and the Pennsylvania Breast Cancer Coalition.

Source:

International Journal of Oncology

DOI:10.3892/ijo.2014.2354

‘All trans-retinoic acid (ATRA) induces re-differentiation of early transformed breast epithelial cells

Authors: Maria Arisi, Rebecca Starker, Sankar Addya, Yong Huang, Sandra Fernandez.  

Related news

Show more

Related products

show more

Innovation: L-Vital C®, true liposomal vitamin C

Innovation: L-Vital C®, true liposomal vitamin C

CAPSULARIS | 14-Apr-2021 | Product Brochure

Did you know that the liquid liposomal vitamin is the form of vitamin C that is best utilized by the body? Liposomes need aqueous solutions to live and...

SLENDACOR® Weight Management Complex

SLENDACOR® Weight Management Complex

PLT Health Solutions | 13-Apr-2021 | Product Brochure

For many of us, maintaining a healthy weight can be tedious and difficult. We could all use a little positive reinforcement along our journey. Slendacor...

The New Normal in Nutraceutical Supplements

The New Normal in Nutraceutical Supplements

ACG | 15-Mar-2021 | Technical / White Paper

With highly evolving health trends and immunity taking centre stage, a tectonic shift in interest among consumers from reactive to proactive healthcare...

HydroCurc + Fe = Smart Formula

HydroCurc + Fe = Smart Formula

Gencor | 02-Mar-2021 | Clinical Study

Iron deficiency is the most prevalent micronutrient deficiency in the world and can have impacts on physical and mental health. A critical micronutrient...

Related suppliers

Follow us

Products

View more

Webinars