European ash tree extract reduces fatty livers: Mice study

By Shane STARLING

- Last updated on GMT

“…this study suggests that long term administration Glucevia prevents hepatic steatosis in [diabetic] mice, probably mediated by glucose homeostasis and insulin resistance improvements.”
“…this study suggests that long term administration Glucevia prevents hepatic steatosis in [diabetic] mice, probably mediated by glucose homeostasis and insulin resistance improvements.”

Related tags: Obesity

Extracts from the common European ash tree (Fraxinus excelsior L.) have been shown to moderate post-prandial insulin response and lower fatty deposits in livers in a study of diabetic mice.

The mice fed Naturex’s Glucevia extract had lower blood glucose levels two hours after feeding compared to the control group and ‘chronic administration’ of it in mice on high-fat diets reduced fatty liver incidence by 66.7%.

Researchers from the University of Murcia in southern Spain randomly divided 20 5-week old mice into ‘standard chow’ and chow fortified with Glucevia at 0.07%.

“A significant reduction in plasma levels of triglycerides accompanied by a reduction in fasting plasma glucose and body weight were found in Zucker rats fed with the extract for 5 weeks,”​ the researchers found.

The intervention lasted 28 weeks with the researchers suggesting it can be an effective treatment for non-alcoholic fatty liver disease.

“…this study suggests that long term administration Glucevia prevents hepatic steatosis in [diabetic] mice, probably mediated by glucose homeostasis and insulin resistance improvements.”

They called for further studies “to generate mechanistic insight on steatosis prevention and to identify companion biomarkers…”.

Naturex R&D director Dr Antoine Bily said: “We will continue investigating Glucevia’s hepatoprotective function because non-alcoholic fatty liver disease is the main manifestation of insulin resistance and is linked to metabolic syndrome."

“Currently, only a few preventive supplements exist and there is no evidence-based approved therapy to manage this common chronic disease in Western countries.”

Source:

Journal of Diabetes & Metabolism

March 2015 (doi: 10.4172/2155-6156.1000527)

‘Preventive Effect of a Fraxinus Excelsior L Seeds/Fruits Extract on Hepatic Steatosis in Obese Type 2 Diabetic Mice’

Authors: Garcia FG, Flanagan J, Molina OG, Vivo VV, Carrillo NG, et al. 

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